| Immune responses to RNA-virus infections of the CNS. | |
| | |
MedLine Citation:
|
PMID: 12776209 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
A successful outcome for the host of virus infection of the central nervous system (CNS) requires the elimination of the virus without damage to essential non-renewable cells, such as neurons. As a result, inflammatory responses must be tightly controlled, and many unique mechanisms seem to contribute to this control. In addition to being important causes of human disease, RNA viruses that infect the CNS provide useful models in which to study immune responses in the CNS. Recent work has shown the importance of innate immune responses in the CNS in controlling virus infection. And advances have been made in assessing the relative roles of cytotoxic T cells, antibodies and cytokines in the clearance of viruses from neurons, glial cells and meningeal cells. |
| | |
Authors:
|
Diane E Griffin |
Related Documents
:
|
8774799 - Regional macrophage activation after injury and the compartmentalization of inflammatio... 15495269 - Astrocyte intermediate filaments in cns pathologies and regeneration. 12473019 - Cytokines and cognition--the case for a head-to-toe inflammatory paradigm. 9723129 - Inflammation in the cns: balance between immunological privilege and immune responses. 19660659 - Progesterone as a neuroprotective factor in traumatic and ischemic brain injury. 1669689 - Microglia: immune network in the cns. 20179769 - Mechanistic issues of the interaction of the hairpin-forming domain of tbid with mitoch... 21450529 - Laquinimod in multiple sclerosis. 17537989 - Anti-inflammatory property of the cannabinoid receptor-2-selective agonist jwh-133 in a... |
Publication Detail:
|
Type: Journal Article; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
|
Title: Nature reviews. Immunology Volume: 3 ISSN: 1474-1733 ISO Abbreviation: Nat. Rev. Immunol. Publication Date: 2003 Jun |
Date Detail:
|
Created Date: 2003-05-30 Completed Date: 2003-07-10 Revised Date: 2008-11-21 |
Medline Journal Info:
|
Nlm Unique ID: 101124169 Medline TA: Nat Rev Immunol Country: England |
Other Details:
|
Languages: eng Pagination: 493-502 Citation Subset: IM |
Affiliation:
|
W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA. dgriffin@jhsph.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Antibodies, Viral / immunology Central Nervous System Infections / immunology*, virology Cytokines / immunology Disease Models, Animal Humans Immunity, Active Immunity, Cellular Immunity, Innate Mice Neurons / immunology, virology RNA Virus Infections / immunology* T-Lymphocytes, Cytotoxic / immunology |
| Chemical | |
Reg. No./Substance:
|
0/Antibodies, Viral; 0/Cytokines |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Transcriptional analysis of targets in multiple sclerosis.
Next Document: Therapeutic vaccines against HIV need international partnerships.