| Immune responses and increased training of the elite athlete. | |
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MedLine Citation:
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PMID: 1447096 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Ten elite male runners (age, 29.8 +/- 1.7 yr; maximum oxygen consumption, 65.3 +/- 4.9 ml.kg-1.min-1; 10-km times, 31 min 43 s +/- 1 min 46 s) deliberately increased training schedules by an average of 38% for 3 wk. Resting heart rate and maximal oxygen intake were unchanged, but the heart rate response to acute exercise was decreased. Following heavy training, blood samples taken at rest showed trends to a decreased helper/suppressor cell ratio, an increased phytohemagglutinin (PHA)- and concanavalin (ConA)-stimulated lymphocyte proliferation, and a decreased production of immunoglobulins IgG and IgM. Whereas PHA-stimulated lymphocyte proliferation was initially unchanged by acute exercise, after 3 wk of heavy training the same acute exercise caused an 18% suppression of proliferation. Acute exercise following heavy training did not alter pokeweed-stimulated IgG or IgM synthesis. There was no correlation between changes in lymphocyte subpopulations, helper/suppressor ratios, and mitogen-induced cellular proliferation. The immune system of endurance-trained athletes at rest seemed to tolerate the stress of heavy training, but superimposition of a bout of acute exercise on the chronic stress of heavy training resulted in immunosuppression, which was transient and most likely not of clinical significance. |
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Authors:
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T J Verde; S G Thomas; R W Moore; P Shek; R J Shephard |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of applied physiology (Bethesda, Md. : 1985) Volume: 73 ISSN: 8750-7587 ISO Abbreviation: J. Appl. Physiol. Publication Date: 1992 Oct |
Date Detail:
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Created Date: 1992-12-29 Completed Date: 1992-12-29 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8502536 Medline TA: J Appl Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1494-9 Citation Subset: IM |
Affiliation:
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Department of Community Health, Faculty of Medicine, University of Toronto, Ontario, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antibody Formation / physiology Exercise / physiology Humans Immunity / physiology* Immunity, Cellular / drug effects Immunoglobulins / biosynthesis Lymphocyte Activation / immunology Male Oxygen Consumption / drug effects, physiology Physical Education and Training* Pokeweed Mitogens / pharmacology Running |
| Chemical | |
Reg. No./Substance:
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0/Immunoglobulins; 0/Pokeweed Mitogens |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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