Document Detail


Immune responses and increased training of the elite athlete.
MedLine Citation:
PMID:  1447096     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Ten elite male runners (age, 29.8 +/- 1.7 yr; maximum oxygen consumption, 65.3 +/- 4.9 ml.kg-1.min-1; 10-km times, 31 min 43 s +/- 1 min 46 s) deliberately increased training schedules by an average of 38% for 3 wk. Resting heart rate and maximal oxygen intake were unchanged, but the heart rate response to acute exercise was decreased. Following heavy training, blood samples taken at rest showed trends to a decreased helper/suppressor cell ratio, an increased phytohemagglutinin (PHA)- and concanavalin (ConA)-stimulated lymphocyte proliferation, and a decreased production of immunoglobulins IgG and IgM. Whereas PHA-stimulated lymphocyte proliferation was initially unchanged by acute exercise, after 3 wk of heavy training the same acute exercise caused an 18% suppression of proliferation. Acute exercise following heavy training did not alter pokeweed-stimulated IgG or IgM synthesis. There was no correlation between changes in lymphocyte subpopulations, helper/suppressor ratios, and mitogen-induced cellular proliferation. The immune system of endurance-trained athletes at rest seemed to tolerate the stress of heavy training, but superimposition of a bout of acute exercise on the chronic stress of heavy training resulted in immunosuppression, which was transient and most likely not of clinical significance.
Authors:
T J Verde; S G Thomas; R W Moore; P Shek; R J Shephard
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  73     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  1992 Oct 
Date Detail:
Created Date:  1992-12-29     Completed Date:  1992-12-29     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1494-9     Citation Subset:  IM    
Affiliation:
Department of Community Health, Faculty of Medicine, University of Toronto, Ontario, Canada.
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MeSH Terms
Descriptor/Qualifier:
Adult
Antibody Formation / physiology
Exercise / physiology
Humans
Immunity / physiology*
Immunity, Cellular / drug effects
Immunoglobulins / biosynthesis
Lymphocyte Activation / immunology
Male
Oxygen Consumption / drug effects,  physiology
Physical Education and Training*
Pokeweed Mitogens / pharmacology
Running
Chemical
Reg. No./Substance:
0/Immunoglobulins; 0/Pokeweed Mitogens

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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