Document Detail

Immune responses during pregnancy and the development of allergic disease.
MedLine Citation:
PMID:  9455773     Owner:  NLM     Status:  MEDLINE    
It is now established that allergen exposure in the first few months of life is important in the development of specific allergic sensitisation (1, 2). Furthermore, the immune response of infants born to families with a strong history of allergic disease is relatively immature at birth in comparison to infants with no family history of allergies, with reduced production of Interferon-gamma (IFN-gamma) (3-5) and lower levels of T cell activation and memory (6). It therefore seems logical that the interaction of these two factors must be important in the ontogeny of allergic disease.
J A Warner; C A Jones; A C Jones; E A Miles; T Francis; J O Warner
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology     Volume:  8     ISSN:  0905-6157     ISO Abbreviation:  Pediatr Allergy Immunol     Publication Date:  1997  
Date Detail:
Created Date:  1998-03-13     Completed Date:  1998-03-13     Revised Date:  2008-05-28    
Medline Journal Info:
Nlm Unique ID:  9106718     Medline TA:  Pediatr Allergy Immunol     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  5-10     Citation Subset:  IM    
University Child Health, University of Southampton, UK.
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MeSH Terms
Allergens / immunology*
Embryonic and Fetal Development / immunology*
Hypersensitivity / etiology*,  immunology
Immune System / embryology*
Pregnancy / immunology*
Reg. No./Substance:

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