| Immune responses during and after exercise of constant and alternating intensity above the lactate threshold. | |
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MedLine Citation:
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PMID: 20842100 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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AIM: Intense and prolonged exercise greatly affects circulating cytokine levels. The purpose of this study was to investigate the possible changes in tumour necrosis factor -a (TNF-a), interleukin 6 (IL-6) and cortisol concentrations during and after prolonged exercise of constant and alternating intensity of the same duration and total work performed. METHODS: Ten male subjects underwent two main cycling exercise trials lasting one hour each. On one occasion, exercise intensity was alternated between 46.5±1.9% of maximal oxygen uptake (VO2max ) for 40 s and 120% of VO2max for 20 s, so that the mean intensity corresponded to 105% of the lactate threshold. On the other occasion, exercise intensity was constant at 105% of the lactate threshold. Levels of TNF-a, IL-6 after lipo polysaccharide (LPS) stimulation as well as cortisol were measured at rest, 30 and 60 minutes of exercise and 1 hour after. RESULTS: No significant differences were observed in TNF-a concentrations between the two exercise protocols (P= 0.75), but there was a significant time effect (P<0.01). TNF-a was increased in both groups from a resting value of 436.1±102.5 to 649.5±187.7 pg/mL (P<0.05) at the end of exercise and was subsequently decreased 1 hour post exercise to 305.9±78.8 pg/mL (P<0.01). No significant difference in IL-6 and cortisol concentrations was observed between the two exercise protocols (P=0.13, P=0.10 accordingly). CONCLUSION: In conclusion, prolonged constant and alternating intensity exercise of the same mean intensity and duration seemed to provoke similar changes in aspects of immune response in healthy subjects. |
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Authors:
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S Spanoudaki; M Maridaki; M Tsironi; G Baltopoulos; G C Bogdanis; P Baltopoulos |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of sports medicine and physical fitness Volume: 50 ISSN: 0022-4707 ISO Abbreviation: J Sports Med Phys Fitness Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-09-15 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0376337 Medline TA: J Sports Med Phys Fitness Country: Italy |
Other Details:
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Languages: eng Pagination: 363-70 Citation Subset: IM |
Affiliation:
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Department of Sports Medicine & Biology of Physical Activity, Faculty of Physical Education and Sports Science, University of Athens, Athens, Greece - sspanoud@yahoo.gr. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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