Document Detail


Immune responses after acute ischemic stroke or myocardial infarction.
MedLine Citation:
PMID:  21078527     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
BACKGROUND: We recently demonstrated an immediate immunodepressive state after acute ischemic stroke in humans.
METHODS: In the present study, we prospectively analyzed immune responses in patients with middle cerebral artery stroke (n=20), acute myocardial infarction (n=20) and healthy controls (n=20, also matched for age and gender).
RESULTS: Compared to controls, a rapid depression of monocytic HLA-DR expression and a defective lymphocytic IFN-γ production was obvious after ischemic stroke or myocardial infarction, while total counts of leukocytes and monocytes were significantly higher after myocardial infarction. A T cell-mediated lymphopenia was accentuated in patients with severe stroke, obviously predisposing these patients for nosocomial infections.
CONCLUSIONS: Our data reveal an immediate and to some extent differential suppression of cell-mediated immune responses after ischemic stroke or myocardial infarction respectively.
Authors:
Karl Georg Haeusler; Wolf U H Schmidt; Fabian Foehring; Christian Meisel; Christoph Guenther; Peter Brunecker; Claudia Kunze; Thomas Helms; Ulrich Dirnagl; Hans-Dieter Volk; Arno Villringer
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Publication Detail:
Type:  Journal Article     Date:  2010-11-13
Journal Detail:
Title:  International journal of cardiology     Volume:  155     ISSN:  1874-1754     ISO Abbreviation:  Int. J. Cardiol.     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-02-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  372-7     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.
Affiliation:
Department of Neurology, Charité University Medicine Berlin, Germany; Center for Stroke Research, Charité, Berlin, Germany.
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