| Immune response to maedi-visna virus. | |
| | |
MedLine Citation:
|
PMID: 17127400 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The ovine maedi-visna virus (MVV) was the first lentivirus to be isolated and characterized 1957 in Iceland. MVV leads to a life-long, persistent infection with slow development of lesions in the lung and the central nervous system (CNS). The main target cells of MVV are of the monocyte/macrophage lineage and it does not infect T-lymphocytes or cause immune suppression like human immune deficiency virus (HIV). In spite of a fairly good immune response, including both neutralizing antibodies and cytotoxic T lymphocytes, the virus persists in the host and establishes a life-long infection. There are strong indications that the pathological lesions are immune-mediated and vaccination attempts have not only failed to induce sterile immunity but have occasionally caused increased viremia and more severe disease. |
| | |
Authors:
|
Sigurbjorg Torsteinsdottir; Valgerdur Andresdottir; Hallgrimur Arnarson; Gudmundur Petursson |
Publication Detail:
|
Type: Journal Article; Review Date: 2007-01-01 |
Journal Detail:
|
Title: Frontiers in bioscience : a journal and virtual library Volume: 12 ISSN: 1093-4715 ISO Abbreviation: Front. Biosci. Publication Date: 2007 |
Date Detail:
|
Created Date: 2006-11-27 Completed Date: 2007-08-23 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9709506 Medline TA: Front Biosci Country: United States |
Other Details:
|
Languages: eng Pagination: 1532-43 Citation Subset: IM |
Affiliation:
|
Institute for Experimental Pathology, University of Iceland, Keldur vid Vesturlandsveg, IS112 Reykjavik, Iceland. sibbath@hi.is |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Antibody Formation Immunity, Cellular Pneumonia, Progressive Interstitial, of Sheep / immunology*, prevention & control Sheep Viral Vaccines Visna / immunology*, prevention & control Visna-maedi virus / immunology* |
| Chemical | |
Reg. No./Substance:
|
0/Viral Vaccines |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Cell dynamics and immune response to BLV infection: a unifying model.
Next Document: Immune control and prevention of chronic Friend retrovirus infection.