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Immune response to chemically modified proteome.
MedLine Citation:
PMID:  24375944     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Both enzymatic and non-enzymatic post translational modification (PTM) of proteins involves chemical modifications. Some of these modifications are prerequisite for normal functioning of the cell. While other chemical modifications render them as 'neo-self' antigens, which are recognized as "non-self" leading to aberrant cellular and humoral immune responses. However, these modifications could be secondary effect of autoimmune diseases, as in the case of type I diabetes, hyperglycemia leads to protein glycation. The enigma of chemical modifications and immune response is akin to the 'chick and egg' paradox. Nevertheless, chemical modifications regulate immune response. In some of the well known autoimmune diseases such as Rheumatoid Arthritis, Systemic Lupus Erythematosus and Multiple Sclerosis, chemically modified proteins act as autoantigens forming immune complexes. In some instances, chemical modifications are also involved in regulating immune response during pathogen infection. Further, the usefulness of proteomic analysis of immune complexes is briefly discussed. This article is protected by copyright. All rights reserved.
Authors:
Shweta Bhat; Sheon Mary; Reema Banarjee; Ashok P Giri; Mahesh J Kulkarni
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-12-23
Journal Detail:
Title:  Proteomics. Clinical applications     Volume:  -     ISSN:  1862-8354     ISO Abbreviation:  Proteomics Clin Appl     Publication Date:  2013 Dec 
Date Detail:
Created Date:  2013-12-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101298608     Medline TA:  Proteomics Clin Appl     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
This article is protected by copyright. All rights reserved.
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