| Immune response to H. pylori. | |
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MedLine Citation:
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PMID: 17007009 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The gastric mucosa separates the underlying tissue from the vast array of antigens that traffic through the stomach lumen. While the extreme pH of this environment is essential in aiding the activation of enzymes and food digestion, it also renders the gastric epithelium free from bacterial colonization, with the exception of one important human pathogen, H. pylori. This bacterium has developed mechanisms to survive the harsh environment of the stomach, actively move through the mucosal layer, attach to the epithelium, evade immune responses, and achieve persistent colonization. While a hallmark of this infection is a marked inflammatory response with the infiltration of various immune cells into the infected gastric mucosa, the host immune response is unable to clear the infection and may actually contribute to the associated pathogenesis. Here, we review the host responses involved during infection with H. pylori and how they are influenced by this bacterium. |
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Authors:
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Giovanni Suarez; Victor E Reyes; Ellen J Beswick |
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Publication Detail:
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Type: Editorial; Research Support, N.I.H., Extramural; Review |
Journal Detail:
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Title: World journal of gastroenterology : WJG Volume: 12 ISSN: 1007-9327 ISO Abbreviation: World J. Gastroenterol. Publication Date: 2006 Sep |
Date Detail:
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Created Date: 2006-09-28 Completed Date: 2006-11-30 Revised Date: 2007-12-03 |
Medline Journal Info:
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Nlm Unique ID: 100883448 Medline TA: World J Gastroenterol Country: China |
Other Details:
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Languages: eng Pagination: 5593-8 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antibodies, Bacterial
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immunology Antigens, Bacterial / immunology Gastric Mucosa / immunology*, microbiology, pathology Helicobacter Infections / immunology*, pathology Helicobacter pylori / immunology, pathogenicity* Humans Immunity, Mucosal / immunology T-Lymphocytes / pathology |
| Grant Support | |
ID/Acronym/Agency:
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DK50669/DK/NIDDK NIH HHS; DK56338/DK/NIDDK NIH HHS; T32 AI007536-06/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Bacterial; 0/Antigens, Bacterial |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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