Document Detail

Immune response and prevalence of antibody to Norwalk enteritis virus as determined by radioimmunoassay.
MedLine Citation:
PMID:  118178     Owner:  NLM     Status:  MEDLINE    
A solid-phase microtiter radioimmunoassay was established for the detection of Norwalk virus and its antibody, with clinical materials from human volunteers previously studied in Massachusetts as reagents. A study of 308 Massachusetts residents showed that serum antibody to Norwalk agent was rarely present during childhood but was detectable in approximately 50% of adults. All volunteers inoculated with Norwalk virus who developed illness seroconverted (10/10), whereas only one-third (5/15) of nonill volunteers seroconverted (P = 0.0009). The 10 nonill, nonseroconverting subjects had undetectable to low preexisting antibody levels. Paradoxically, 10/13 subjects with preexisting antibody became ill, whereas 17/25 lacking antibody did not (P = 0.009). All 3 subjects with preexisting anti-Norwalk radioimmunoassay blocking activity in duodenal intraluminal fluids became ill, whereas only 5/11 lacking such activity developed illness (P = 0.15). These data further support the unique concept that some individuals are susceptible to repeated infections with this agent, whereas others are incapable of developing infection.
N R Blacklow; G Cukor; M K Bedigian; P Echeverria; H B Greenberg; D S Schreiber; J S Trier
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of clinical microbiology     Volume:  10     ISSN:  0095-1137     ISO Abbreviation:  J. Clin. Microbiol.     Publication Date:  1979 Dec 
Date Detail:
Created Date:  1980-03-24     Completed Date:  1980-03-24     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7505564     Medline TA:  J Clin Microbiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  903-9     Citation Subset:  IM    
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MeSH Terms
Age Factors
Antibodies, Viral / analysis*,  biosynthesis
Child, Preschool
Gastroenteritis / immunology*,  microbiology
Middle Aged
Milk, Human / immunology
Virus Diseases / immunology*,  microbiology
Viruses, Unclassified / immunology*
Reg. No./Substance:
0/Antibodies, Viral

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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