| Immune response of chicken gut to natural colonization by gut microflora and to Salmonella enterica serovar enteritidis infection. | |
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MedLine Citation:
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PMID: 21555397 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In commercial poultry production, there is a lack of natural flora providers since chickens are hatched in the clean environment of a hatchery. Events occurring soon after hatching are therefore of particular importance, and that is why we were interested in the development of the gut microbial community, the immune response to natural microbial colonization, and the response to Salmonella enterica serovar Enteritidis infection as a function of chicken age. The complexity of chicken gut microbiota gradually increased from day 1 to day 19 of life and consisted of Proteobacteria and Firmicutes. For the first 3 days of life, chicken cecum was protected by increased expression of chicken β-defensins (i.e., gallinacins 1, 2, 4, and 6), expression of which dropped from day 4 of life. On the other hand, a transient increase in interleukin-8 (IL-8) and IL-17 expression could be observed in chicken cecum on day 4 of life, indicating physiological inflammation and maturation of the gut immune system. In agreement, the response of chickens infected with S. Enteritidis on days 1, 4, and 16 of life shifted from Th1 (characterized mainly by induction of gamma interferon [IFN-γ] and inducible nitric oxide synthase [iNOS]), observed in younger chickens, to Th17, observed in 16-day-old chickens (characterized mainly by IL-17 induction). Active modification of chicken gut microbiota in the future may accelerate or potentiate the maturation of the gut immune system and increase its resistance to infection with different pathogens. |
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Authors:
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Magdalena Crhanova; Helena Hradecka; Marcela Faldynova; Marta Matulova; Hana Havlickova; Frantisek Sisak; Ivan Rychlik |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2011-05-09 |
Journal Detail:
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Title: Infection and immunity Volume: 79 ISSN: 1098-5522 ISO Abbreviation: Infect. Immun. Publication Date: 2011 Jul |
Date Detail:
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Created Date: 2011-06-21 Completed Date: 2011-09-02 Revised Date: 2012-01-02 |
Medline Journal Info:
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Nlm Unique ID: 0246127 Medline TA: Infect Immun Country: United States |
Other Details:
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Languages: eng Pagination: 2755-63 Citation Subset: IM |
Affiliation:
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Veterinary Research Institute, Hudcova 70, 621 00 Brno, Czech Republic. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aging Animals Cecum / immunology, microbiology Chickens / immunology*, microbiology* Cytokines / metabolism Enteritis Enzyme-Linked Immunosorbent Assay Gastrointestinal Tract / immunology*, microbiology* Immunity, Innate Interleukin-17 / biosynthesis, metabolism Interleukin-8 / metabolism Polymerase Chain Reaction Poultry Diseases / immunology*, microbiology Proteobacteria RNA, Ribosomal, 16S Salmonella Infections, Animal / immunology* Salmonella enteritidis / growth & development, immunology* Th1 Cells / immunology Th17 Cells / immunology beta-Defensins / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Cytokines; 0/Interleukin-17; 0/Interleukin-8; 0/RNA, Ribosomal, 16S; 0/beta-Defensins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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