Document Detail

Immune response of calves experimentally infected with non-cell-culture-passaged bovine respiratory syncytial virus.
MedLine Citation:
PMID:  9687869     Owner:  NLM     Status:  MEDLINE    
The immune response of calves was studied following infection with non-cell-passaged Bovine respiratory syncytial virus (BRSV). Two groups of 6 specific pathogen free (SPF) calves were housed in separate isolation rooms. One group was inoculated intranasally with a non-cell-passaged BRSV strain and the control group was mock-infected. A BRSV specific antibody response was observed for all the BRSV infected calves. These antibodies were shown to have neutralizing activity. No lymphocyte proliferation response was detected in the mock-infected group whereas three animals in the infected group were positive three weeks after the infection. All BRSV-infected calves, except one, produced interferon-gamma (IFN-gamma) one week post-infection and IFN-gamma was observed in all six infected calves after three weeks. The control group showed no IFN-gamma synthesis. In spite of the limits of the BRSV infection model, humoral and cellular immune responses were actively developed by all the calves against this pathogen.
I Knott; V Weynants; K Walravens; W H van der Poel; J A Kramps; J J Letesson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Archives of virology     Volume:  143     ISSN:  0304-8608     ISO Abbreviation:  Arch. Virol.     Publication Date:  1998  
Date Detail:
Created Date:  1998-08-13     Completed Date:  1998-08-13     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7506870     Medline TA:  Arch Virol     Country:  AUSTRIA    
Other Details:
Languages:  eng     Pagination:  1119-28     Citation Subset:  IM    
Lab. Immunologie, URBM, Facultés Universitaires Notre-Dame de la Paix, Namur, Belgium.
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MeSH Terms
Interferon-gamma / biosynthesis
Lymphocyte Activation
Respiratory Syncytial Virus Infections / immunology*
Respiratory Syncytial Virus, Bovine*
Reg. No./Substance:

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