Document Detail


Immune-related edemagenic activity of glutamines and glutamic acid, components of immunomodulatory agents.
MedLine Citation:
PMID:  7879704     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A number of compounds, in their structure similar to the immunomodulatory agent adamantylamide-L-alanyl-D-isoglutamine (AdDP), a desmuramyl analog of muramyl dipeptide (MDP), were compared with respect to their in vivo immunobiological activity. The agents were represented by adamantylamide-peptides or -amino acids differing principally in the nature of glutaminyl moieties. They were all able to induce inflammatory reaction which was prevented by anti-T-cell (TH) mAb, silica, indomethacin and dexamethasone. Responsible for this effect proved to be glutaminyl moieties (glutamine, isoglutamine, or glutamic acid), irrespective of their stereospecificity. Unlike the immunomodulatory molecule of AdDP, neither of the compounds and amino acids were able to stimulate production of antibodies in immunized animals, however.
Authors:
Z Zídek
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Agents and actions     Volume:  42     ISSN:  0065-4299     ISO Abbreviation:  Agents Actions     Publication Date:  1994 Oct 
Date Detail:
Created Date:  1995-04-05     Completed Date:  1995-04-05     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0213341     Medline TA:  Agents Actions     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  163-6     Citation Subset:  IM    
Affiliation:
Institute of Pharmacology, Academy of Sciences of Czech Republic, Prague.
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MeSH Terms
Descriptor/Qualifier:
Adjuvants, Immunologic / chemistry,  pharmacology*,  toxicity*
Amantadine / analogs & derivatives*,  pharmacology
Amino Acid Sequence
Animals
Anti-Inflammatory Agents, Non-Steroidal / pharmacology
Antibodies, Monoclonal / immunology
Dipeptides / pharmacology*
Edema / chemically induced*,  immunology*
Female
Glutamic Acid / chemistry,  toxicity*
Glutamine / chemistry,  toxicity*
Hemolytic Plaque Technique
Mice
Mice, Inbred C57BL
Molecular Sequence Data
Structure-Activity Relationship
Chemical
Reg. No./Substance:
0/Adjuvants, Immunologic; 0/Anti-Inflammatory Agents, Non-Steroidal; 0/Antibodies, Monoclonal; 0/Dipeptides; 56-85-9/Glutamine; 56-86-0/Glutamic Acid; 768-94-5/Amantadine; 89813-21-8/adamantylamide-alanyl-isoglutamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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