Document Detail


Immune regulation in myasthenia gravis: evidence for an increased suppressor T-cell population.
MedLine Citation:
PMID:  6216848     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The production of anti-acetylcholine receptor antibodies in myasthenia gravis represents a persistent and unexplained break in self-tolerance. The studies reported here demonstrate an altered regulatory T-cell population with an increase in the percentage of circulating T-suppressor cells as defined by two independently developed murine monoclonal antibody markers. Leu 2a- and OKT8a-positive cells were significantly increased within the T-cell population in myasthenia gravis (25.0 +/- 6.4% versus 20.7 +/- 2.9% and 34.9 +/- 7.0% versus 26.0 +/- 3.2%, respectively) compared to an age- and sex-equivalent group. In addition, the circulating total T-cell population was reduced in myasthenia gravis. Patients with symptomatically uncontrolled disease (with or without immunosuppression) demonstrated significantly altered ratios of helper to suppressor T-cells, while patients whose myasthenia symptoms were controlled did not differ from normal subjects.
Authors:
A E Miller; J Hudson; R S Tindall
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Annals of neurology     Volume:  12     ISSN:  0364-5134     ISO Abbreviation:  Ann. Neurol.     Publication Date:  1982 Oct 
Date Detail:
Created Date:  1983-01-19     Completed Date:  1983-01-19     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7707449     Medline TA:  Ann Neurol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  341-7     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Antibodies, Monoclonal / immunology
Child
Cholinesterase Inhibitors / therapeutic use
Cytotoxicity Tests, Immunologic
Female
Humans
Immunosuppressive Agents / therapeutic use
Male
Middle Aged
Myasthenia Gravis / drug therapy,  immunology*
T-Lymphocytes, Regulatory / immunology*
Grant Support
ID/Acronym/Agency:
1-M01-RR0633/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/Cholinesterase Inhibitors; 0/Immunosuppressive Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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