| Immune reconstitution inflammatory syndrome in leprosy. | |
| | |
MedLine Citation:
|
PMID: 21972657 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
|
Immune reconstitution inflammatory syndrome (IRIS) is a paradoxical deterioration in the clinical status of a patient infected with human immunodeficiency virus (HIV) on highly active antiretroviral treatment (HAART). The immune suppression caused by the virus can initially suppress the clinical manifestations of leprosy which can then be unmasked after treatment with HAART or an inflammatory reaction can occur in the initial months of therapy, resulting from dysregulated recovery of immunity to specific antigens. Both these conditions are identified as IRIS in leprosy. Though this syndrome is a widely recognized entity presently, there is still a lack of universally acceptable diagnostic criteria for the condition. The first case published case of leprosy- associated immune reconstitution disease was reported in 2003 and about 47 confirmed cases of IRIS in leprosy have been reported since then, mostly from Brazil and India. Anti-inflammatory drugs and steroids are the drugs of choice in inflammatory episodes with continuation of antiretroviral therapy. With increasing affordability of antiretroviral therapy, clinicians will put more and more number of human immunodeficiency virus infected patients on therapy and hence an increase in the incidence of IRIS is expected. Therefore, it is important to understand all facets of this syndrome which is becoming more prevalent with each passing day. |
| | |
Authors:
|
S Sanghi; R S Grewal; B Vasudevan; N Lodha |
Related Documents
:
|
9368177 - Focal corneal decompensation caused by an anterior capsulotomy remnant. 1583647 - Evidence that rieger syndrome maps to 4q25 or 4q27. 3002107 - The initial stage of the exfoliation syndrome. 508177 - Proliferative endotheliopathy with iris abnormalities. the iridocorneal endothelial syn... 20710137 - Acute radiation syndrome: assessment and management. 1810617 - Acute lower leg compartment syndrome. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Indian journal of leprosy Volume: 83 ISSN: 0254-9395 ISO Abbreviation: Indian J Lepr Publication Date: 2011 Apr-Jun |
Date Detail:
|
Created Date: 2011-10-06 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8409173 Medline TA: Indian J Lepr Country: India |
Other Details:
|
Languages: eng Pagination: 61-70 Citation Subset: IM |
Affiliation:
|
Department of Dermatology, Command Hospital, Wanowrie, Pune-411040, India. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: [Advances in cooperativity and mechanism of combination of Back-shu and Front-mu points].
Next Document: Claw-toes correction: personal technique.