Document Detail


Immune profiles in hepatosplenic schistosomiasis mansoni after surgical treatments.
MedLine Citation:
PMID:  9513076     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The hepatosplenic form of schistosomiasis mansoni sometimes induces bleeding in oesophageal varices that requires surgical treatment. Although splenectomy is often necessary these patients rarely present with septic events, a finding that may be related to changes in the immunological system. To investigate the immunological profiles of patients with schistosomiasis, we studied the B- and T-lymphocyte counts and the immunoglobulin A, G and M (IgA, IgG and IgM) levels in patients treated surgically and in those who were not operated on. Patients who underwent distal splenorenal shunt, preserving the spleen, showed significantly increased T-lymphocyte counts compared with healthy controls. The IgM and IgG levels were significantly increased compared with the healthy controls in patients submitted to partial and total splenectomy, respectively. The IgM level also tended to increase in patients who were not operated on compared with the controls. These results suggest that chronic schistosomiasis may influence the immune system.
Authors:
A Petroianu; L J Antunes
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of international medical research     Volume:  26     ISSN:  0300-0605     ISO Abbreviation:  J. Int. Med. Res.     Publication Date:    1998 Jan-Feb
Date Detail:
Created Date:  1998-04-14     Completed Date:  1998-04-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0346411     Medline TA:  J Int Med Res     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  43-9     Citation Subset:  IM    
Affiliation:
Department of Surgery, Medical School, Federal University of Minas Gerais, Belo Horizonte, Brazil.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
B-Lymphocytes / immunology
Esophageal and Gastric Varices / etiology
Female
Humans
Immunoglobulin A / blood
Immunoglobulin G / blood
Immunoglobulin M / blood
Liver Diseases, Parasitic / immunology*,  surgery
Lymphocyte Count
Male
Middle Aged
Schistosomiasis mansoni / immunology*,  surgery*
Splenectomy
Splenic Diseases / immunology*,  parasitology*,  surgery
T-Lymphocytes / immunology
Chemical
Reg. No./Substance:
0/Immunoglobulin A; 0/Immunoglobulin G; 0/Immunoglobulin M

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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