Document Detail


Immune parameters and morbidity in hard drug and human immunodeficiency virus-exposed but uninfected infants.
MedLine Citation:
PMID:  15121939     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To examine the association of maternal hard drug use (injection drugs, cocaine, and opiates) on lymphocyte subsets and clinical morbidity in uninfected infants who are born to human immunodeficiency virus-infected mothers who were enrolled in the Women and Infants Transmission Study (1990-2000). METHODS: Maternal hard drug use was identified by self-report and/or urine toxicology. Infant evaluations occurred at birth and at 1, 2, 4, 6, 9, 12, 18, and 24 months of age. RESULTS: A total of 401 (28%) of the 1436 uninfected infants were born to drug-using mothers. Maternal CD4 lymphocyte percentage and RNA at delivery were not significantly different between drug users and nonusers. Infants who were born to drug-using mothers had lower mean gestational age (37.8 vs 38.5 weeks) and birth weight (2.9 vs 3.1 kg). Infants with intrauterine drug exposure had lower CD4 lymphocyte percentage over the first 4 months of life after adjusting for covariates and higher natural killer lymphocyte percentage. When the analysis was stratified by time period of entry, the incidence of clinical events was not different between infants who were born to drug users versus nonusers. CONCLUSION: Maternal hard drug use is associated with immunologic changes in infants early in life, although these changes did not seem to be associated with increased risk of infections.
Authors:
Natalie Neu; Robert Leighty; Samuel Adeniyi-Jones; Clemente Diaz; Edward Handelsman; Gary Kaufman; Mary E Paul; Kenneth Rich; Lynne Mofenson; Jane Pitt;
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Pediatrics     Volume:  113     ISSN:  1098-4275     ISO Abbreviation:  Pediatrics     Publication Date:  2004 May 
Date Detail:
Created Date:  2004-05-03     Completed Date:  2004-08-09     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0376422     Medline TA:  Pediatrics     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1260-6     Citation Subset:  AIM; IM    
Affiliation:
Columbia University, New York, New York 10032, USA. nn45@columbia.edu
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MeSH Terms
Descriptor/Qualifier:
Adult
Female
HIV Infections / physiopathology*,  transmission
Humans
Infant
Infant, Newborn
Lymphocyte Subsets*
Morbidity
Pregnancy
Pregnancy Complications / physiopathology
Pregnancy Complications, Infectious / physiopathology*
Prenatal Exposure Delayed Effects*
Substance-Related Disorders / physiopathology*
Grant Support
ID/Acronym/Agency:
1 U01 AI 50274-01/AI/NIAID NIH HHS; 9U01 DA 15054/DA/NIDA NIH HHS; N01 AI 85339/AI/NIAID NIH HHS; RR00188/RR/NCRR NIH HHS; RR00645/RR/NCRR NIH HHS; U01 AI 34841/AI/NIAID NIH HHS; U01 AI 34858/AI/NIAID NIH HHS; U01 DA 15053/DA/NIDA NIH HHS; U01 HD 36117/HD/NICHD NIH HHS; U01 HD 41983/HD/NICHD NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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