| Immune and non-immune functions of the immunoproteasome. | |
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MedLine Citation:
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PMID: 22201844 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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The biological importance of the ubiquitin-proteasome system in the control of myriad cellular processes has been well-recognized; however, the pathophysiological significance of the immunoproteasome, the inducible form of the proteasome, has not been well-comprehended until lately. The primary function of the immunoproteasome was originally believed to improve MHC-I antigen presentation. It now becomes evident that the immunoproteasome possesses broader biological functions. It regulates proinflammatory cytokine production, and T cell differentiation and proliferation. Alongside immune functions, the immunoproteasome has been demonstrated to relieve oxidative stress by the efficient turnover of oxidatively-damaged proteins and by allaying the formation of harmful protein aggregates. Furthermore, it has been implicated to regulate tumor cell growth and control muscle mass. Finally, the immunoproteasome has recently drawn considerable attention as a potential novel therapeutic target for cancer and autoimmune disease. This review will give an overview of the structure and function of the immunoproteasome, highlight its functional diversity in both immune and non-immune responses, and discuss the relationship between the dysregulation of the immunoproteasome and the development of several human diseases. (Words: 174). |
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Authors:
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Arkhjamil Angeles; Gabriel Fung; Honglin Luo |
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Publication Detail:
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Type: Journal Article Date: 2012-01-01 |
Journal Detail:
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Title: Frontiers in bioscience : a journal and virtual library Volume: 17 ISSN: 1093-4715 ISO Abbreviation: Front. Biosci. Publication Date: 2012 |
Date Detail:
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Created Date: 2011-12-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9709506 Medline TA: Front Biosci Country: United States |
Other Details:
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Languages: eng Pagination: 1904-16 Citation Subset: IM |
Affiliation:
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UBC James Hogg iCAPTURE Centre, Institute for Heart and Lung Health, St. Paul's Hospital, Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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