Document Detail

Immune modulators in the context of the ovulatory process: a role for interleukin-1.
MedLine Citation:
PMID:  8962646     Owner:  NLM     Status:  MEDLINE    
Recent studies have established the existence of a complete intraovarian interleukin-1 system replete with ligands, receptors, and a receptor antagonist. This article examines the hypothesis that intraovarian IL-1 may play an intermediary role in the ovulatory process. More specifically, it is hypothesized that intraovarian IL-1 beta may constitute a mediator of gonadotropins in the induction of ovulation, an effector capable of coordinating and amplifying key components of the ovulatory cascade. The insight derived from this investigation may result the elucidation of some of the molecular events underlying the ovulatory process, in the delineation of the reproductive side effects of systemic anti-IL-1 therapy, and in potentially improved strategies for the promotion of fertility or its control.
E Y Adashi
Related Documents :
25369526 - Correction: exploring the impact of bdnf val66met genotype on serotonin transporter and...
20511226 - Targeting of tumor necrosis factor receptor 1 to low density plasma membrane domains in...
8556346 - Intracerebroventricular interleukin-1 receptor antagonist blocks the enhancement of fea...
1663076 - Tumour necrosis factor receptor distribution in human lymphoid tissue.
25379676 - Visualization of oxytocin release that mediates paired pulse facilitation in hypothalam...
15014066 - A tm2 residue in the beta1 subunit determines spontaneous opening of homomeric and hete...
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  American journal of reproductive immunology (New York, N.Y. : 1989)     Volume:  35     ISSN:  1046-7408     ISO Abbreviation:  Am. J. Reprod. Immunol.     Publication Date:  1996 Mar 
Date Detail:
Created Date:  1996-12-24     Completed Date:  1996-12-24     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8912860     Medline TA:  Am J Reprod Immunol     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  190-4     Citation Subset:  IM    
Department of Obstetrics/Gynecology, University of Maryland School of Medicine, Baltimore, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Adjuvants, Immunologic / physiology*
Interleukin-1 / physiology*
Ovulation / drug effects,  immunology*
Grant Support
Reg. No./Substance:
0/Adjuvants, Immunologic; 0/Interleukin-1

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Update on the Center for Recombinant Gamete Contraceptive Vaccinogens.
Next Document:  Luminal and glandular endometrial epithelium express integrins differentially throughout the menstru...