| Immune modulators in the context of the ovulatory process: a role for interleukin-1. | |
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MedLine Citation:
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PMID: 8962646 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Recent studies have established the existence of a complete intraovarian interleukin-1 system replete with ligands, receptors, and a receptor antagonist. This article examines the hypothesis that intraovarian IL-1 may play an intermediary role in the ovulatory process. More specifically, it is hypothesized that intraovarian IL-1 beta may constitute a mediator of gonadotropins in the induction of ovulation, an effector capable of coordinating and amplifying key components of the ovulatory cascade. The insight derived from this investigation may result the elucidation of some of the molecular events underlying the ovulatory process, in the delineation of the reproductive side effects of systemic anti-IL-1 therapy, and in potentially improved strategies for the promotion of fertility or its control. |
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Authors:
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E Y Adashi |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
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Title: American journal of reproductive immunology (New York, N.Y. : 1989) Volume: 35 ISSN: 1046-7408 ISO Abbreviation: Am. J. Reprod. Immunol. Publication Date: 1996 Mar |
Date Detail:
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Created Date: 1996-12-24 Completed Date: 1996-12-24 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8912860 Medline TA: Am J Reprod Immunol Country: DENMARK |
Other Details:
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Languages: eng Pagination: 190-4 Citation Subset: IM |
Affiliation:
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Department of Obstetrics/Gynecology, University of Maryland School of Medicine, Baltimore, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adjuvants, Immunologic
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physiology* Animals Female Humans Interleukin-1 / physiology* Ovulation / drug effects, immunology* |
| Grant Support | |
ID/Acronym/Agency:
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HD-30288/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Adjuvants, Immunologic; 0/Interleukin-1 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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