Document Detail


Immune modulators in the context of the ovulatory process: a role for interleukin-1.
MedLine Citation:
PMID:  8962646     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Recent studies have established the existence of a complete intraovarian interleukin-1 system replete with ligands, receptors, and a receptor antagonist. This article examines the hypothesis that intraovarian IL-1 may play an intermediary role in the ovulatory process. More specifically, it is hypothesized that intraovarian IL-1 beta may constitute a mediator of gonadotropins in the induction of ovulation, an effector capable of coordinating and amplifying key components of the ovulatory cascade. The insight derived from this investigation may result the elucidation of some of the molecular events underlying the ovulatory process, in the delineation of the reproductive side effects of systemic anti-IL-1 therapy, and in potentially improved strategies for the promotion of fertility or its control.
Authors:
E Y Adashi
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  American journal of reproductive immunology (New York, N.Y. : 1989)     Volume:  35     ISSN:  1046-7408     ISO Abbreviation:  Am. J. Reprod. Immunol.     Publication Date:  1996 Mar 
Date Detail:
Created Date:  1996-12-24     Completed Date:  1996-12-24     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8912860     Medline TA:  Am J Reprod Immunol     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  190-4     Citation Subset:  IM    
Affiliation:
Department of Obstetrics/Gynecology, University of Maryland School of Medicine, Baltimore, USA.
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MeSH Terms
Descriptor/Qualifier:
Adjuvants, Immunologic / physiology*
Animals
Female
Humans
Interleukin-1 / physiology*
Ovulation / drug effects,  immunology*
Grant Support
ID/Acronym/Agency:
HD-30288/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/Adjuvants, Immunologic; 0/Interleukin-1

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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