Document Detail

Immune modulation of HLA-G dimer in maternal-fetal interface.
MedLine Citation:
PMID:  17587197     Owner:  NLM     Status:  MEDLINE    
HLA-G is a non-classical human MHC class I molecule, which has several characteristics distinct from classical MHC, such as low polymorphism and restricted tissue distribution. HLA-G is expressed on placenta, thymus and some tumors. At the maternal-fetal interface, trophoblasts do not express major classical MHC class I molecules (MHCI), HLA-A and -B, to prevent normal T cell responses. Instead, HLA-G is expressed and can suppress a wide range of immune responses by binding to inhibitory immune cell surface receptors, such as leukocyte Ig-like receptor (LILR) B1 and LILRB2. HLA-G exists in various forms, including beta2m-associated or -free disulfide-linked dimers that can be expressed either at the cell surface or in soluble form. However, until recently the physiological role of these different molecular forms has been unclear. In this issue of the European Journal of Immunology, one article demonstrates that the disulfide-linked homodimer of beta2m-associated HLA-G is the major fraction expressed by trophoblast cells. The HLA-G dimer modulates the function of LILRB1-expressing antigen-presenting cells by principally binding to LILRB1. On the other hand, another recent report showed that beta2m-free disulfide-linked HLA-G dimers are produced by villous cytotrophoblast cells. Taken together, these results provide strong evidence in support of the hypothesis that HLA-G dimers play a role in immune suppression at the maternal-fetal interface. Further in-depth investigation will help to clarify the precise mechanism of HLA-G receptor recognition and signaling in vivo and the role of these interactions in successful reproduction. See accompanying article: (
Kimiko Kuroki; Katsumi Maenaka
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Publication Detail:
Type:  Comment; Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  European journal of immunology     Volume:  37     ISSN:  0014-2980     ISO Abbreviation:  Eur. J. Immunol.     Publication Date:  2007 Jul 
Date Detail:
Created Date:  2007-07-02     Completed Date:  2007-09-14     Revised Date:  2013-06-06    
Medline Journal Info:
Nlm Unique ID:  1273201     Medline TA:  Eur J Immunol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  1727-9     Citation Subset:  IM    
Division of Structural Biology, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan.
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MeSH Terms
Fetus / immunology
HLA Antigens / immunology*
HLA-G Antigens
Histocompatibility Antigens Class I / immunology*
Immune Tolerance*
Placenta / immunology*
Pregnancy / immunology*
Trophoblasts / immunology
Reg. No./Substance:
0/HLA Antigens; 0/HLA-G Antigens; 0/Histocompatibility Antigens Class I
Comment On:
Eur J Immunol. 2007 Jul;37(7):1924-37   [PMID:  17549736 ]

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