Document Detail

Immune mediators of postoperative ileus.
MedLine Citation:
PMID:  22382699     Owner:  NLM     Status:  MEDLINE    
PATHOPHYSIOLOGY: The pathophysiology has been elucidated within the last decades, demonstrating that both, neurogenic and inflammatory mechanisms are involved in response to the surgical trauma. It is now generally accepted that POI pathogenesis processes in two phases: a first neurogenic phase is accountable for the immediate postoperative impairment of bowel motility. This is followed by a second immunological phase that can last for days and mainly affects strength and length of POI. More recent findings demonstrate a bidirectional interaction between the nervous and the immune system, and this interaction significantly contributed to our present understanding of POI pathophysiology. Although nerval mechanisms have a significant impact in the early phase of POI, the contribution of the immune system and subsequently its manipulation has risen as the most promising strategy in prevention or treatment of the clinically relevant prolonged form of POI.
AIMS: The present manuscript will give an update on the inflammatory responses, the involved cell types, and participating immune mediators in POI.
Sven Wehner; Tim O Vilz; Burkhard Stoffels; Joerg C Kalff
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Publication Detail:
Type:  Journal Article; Review     Date:  2012-03-02
Journal Detail:
Title:  Langenbeck's archives of surgery / Deutsche Gesellschaft für Chirurgie     Volume:  397     ISSN:  1435-2451     ISO Abbreviation:  Langenbecks Arch Surg     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-03-29     Completed Date:  2012-09-06     Revised Date:  2013-05-20    
Medline Journal Info:
Nlm Unique ID:  9808285     Medline TA:  Langenbecks Arch Surg     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  591-601     Citation Subset:  IM    
Department of Surgery, University of Bonn, Sigmund-Freud-Str. 25, 53105 Bonn, Germany.
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MeSH Terms
Dendritic Cells / physiology
Ileus / physiopathology*
Inflammation Mediators / blood*
Intestinal Mucosa / physiopathology
Macrophages / physiology
Mast Cells / physiology
Neurogenesis / physiology
Postoperative Complications / physiopathology*
Postoperative Nausea and Vomiting / physiopathology
Reg. No./Substance:
0/Inflammation Mediators

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