| Immune-mediated liver injury: prognostic value of CD4+, CD8+, and CD68+ in infants with extrahepatic biliary atresia. | |
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MedLine Citation:
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PMID: 16080928 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Hepatic fibrosis and cirrhosis develop progressively in extrahepatic biliary atresia (EHBA) despite timely surgical intervention. PURPOSE: The aim of the study was to define CD4+ helper T lymphocytes, cytotoxic CD8+ T lymphocytes, and CD68+ (macrophages) infiltration of portal tracts and lobules and hepatic fibrosis as possible predictive measures of outcome of infants having EHBA. METHODS: The outcome of 32 infants with EHBA was correlated to their percutaneous biopsy and postportoenterostomy core liver tissue infiltration by CD4+, CD68+, and CD8+ cells and to the degree of detected fibrosis. RESULTS: Portoenterostomy cores were heavily infiltrated by CD4+, CD8+, and CD68+, compared with the preoperative liver biopsy (P = .008, .004, and .017, respectively). Infants having favorable outcome had more macrophage infiltration in portoenterostomy core compared with those having an unfavorable outcome (25.66 +/- 29.77 per HPF compared with 11.62 +/- 4.58, P = .000). Mean CD4+/CD8+ ratio was 1.54 +/- 1.37 in those who died within 18 months postoperatively and 0.733 +/- 0.48 in others (P = .021). CONCLUSION: Immune-mediated destruction of portal tracts is an integral part of pathogenesis of EHBA. |
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Authors:
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Magd A Kotb; Ahmed El Henawy; Sahaar Talaat; Mona Aziz; Gamal H El Tagy; Mohamed M El Barbary; Wael Mostafa |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of pediatric surgery Volume: 40 ISSN: 1531-5037 ISO Abbreviation: J. Pediatr. Surg. Publication Date: 2005 Aug |
Date Detail:
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Created Date: 2005-08-05 Completed Date: 2006-02-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0052631 Medline TA: J Pediatr Surg Country: United States |
Other Details:
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Languages: eng Pagination: 1252-7 Citation Subset: IM |
Affiliation:
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Department of Paediatrics, Cairo University, Cairo, Egypt. malotfi@menanet.net |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Analysis of Variance Antigens, CD / analysis, immunology Antigens, CD4 / analysis Antigens, CD8 / analysis Antigens, Differentiation, Myelomonocytic / analysis, immunology Bile Ducts, Extrahepatic / immunology*, pathology Biliary Atresia / complications*, immunology*, surgery Female Humans Immunohistochemistry Infant Infant, Newborn Liver / immunology, pathology Liver Cirrhosis, Biliary / etiology, immunology*, pathology Lymphocyte Count Macrophages / immunology Male Portal System / immunology, pathology Portoenterostomy, Hepatic Prognosis Statistics, Nonparametric T-Lymphocytes, Cytotoxic / immunology T-Lymphocytes, Helper-Inducer / immunology Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD; 0/Antigens, CD4; 0/Antigens, CD8; 0/Antigens, Differentiation, Myelomonocytic; 0/CD68 antigen, human |
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