| Immune-mediated coagulopathy associated with topical bovine thrombin: review of the pediatric literature. | |
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MedLine Citation:
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PMID: 21228719 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Postoperative bleeding may occur from a number of etiologies. An uncommon cause of postoperative bleeding is immune-mediated coagulopathy resulting from reexposure to a topical hemostat containing bovine thrombin. Some patients may develop antibodies to bovine thrombin (and other bovine coagulation proteins present in the product) which cross-react with human coagulation proteins, resulting in a coagulopathy, and occasionally, in serious bleeding and death. Most of the clinical information on this coagulopathy is in the adult medical literature. This article reviews the literature on pediatric cases with this coagulopathy and summarizes clinical outcomes and effective therapies. |
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Authors:
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George M Rodgers |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Journal of pediatric hematology/oncology Volume: 33 ISSN: 1536-3678 ISO Abbreviation: J. Pediatr. Hematol. Oncol. Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-02-23 Completed Date: 2011-04-08 Revised Date: 2011-10-06 |
Medline Journal Info:
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Nlm Unique ID: 9505928 Medline TA: J Pediatr Hematol Oncol Country: United States |
Other Details:
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Languages: eng Pagination: 86-8 Citation Subset: IM |
Affiliation:
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Division of Hematology, University of Utah Health Sciences Center, Salt Lake City, UT 84132, USA. george.rodgers@hsc.utah.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Topical Adolescent Animals Autoantibodies / immunology Blood Coagulation Disorders / chemically induced*, immunology Cattle Child Child, Preschool Cross Reactions Hemostasis, Surgical / adverse effects, methods Hemostatics / administration & dosage, adverse effects*, immunology Humans Infant Postoperative Hemorrhage / chemically induced*, immunology Thrombin / administration & dosage, adverse effects*, immunology |
| Chemical | |
Reg. No./Substance:
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0/Autoantibodies; 0/Hemostatics; EC 3.4.21.5/Thrombin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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