Document Detail

Immune-mediated coagulopathy associated with topical bovine thrombin: review of the pediatric literature.
MedLine Citation:
PMID:  21228719     Owner:  NLM     Status:  MEDLINE    
Postoperative bleeding may occur from a number of etiologies. An uncommon cause of postoperative bleeding is immune-mediated coagulopathy resulting from reexposure to a topical hemostat containing bovine thrombin. Some patients may develop antibodies to bovine thrombin (and other bovine coagulation proteins present in the product) which cross-react with human coagulation proteins, resulting in a coagulopathy, and occasionally, in serious bleeding and death. Most of the clinical information on this coagulopathy is in the adult medical literature. This article reviews the literature on pediatric cases with this coagulopathy and summarizes clinical outcomes and effective therapies.
George M Rodgers
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of pediatric hematology/oncology     Volume:  33     ISSN:  1536-3678     ISO Abbreviation:  J. Pediatr. Hematol. Oncol.     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-02-23     Completed Date:  2011-04-08     Revised Date:  2011-10-06    
Medline Journal Info:
Nlm Unique ID:  9505928     Medline TA:  J Pediatr Hematol Oncol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  86-8     Citation Subset:  IM    
Division of Hematology, University of Utah Health Sciences Center, Salt Lake City, UT 84132, USA.
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MeSH Terms
Administration, Topical
Autoantibodies / immunology
Blood Coagulation Disorders / chemically induced*,  immunology
Child, Preschool
Cross Reactions
Hemostasis, Surgical / adverse effects,  methods
Hemostatics / administration & dosage,  adverse effects*,  immunology
Postoperative Hemorrhage / chemically induced*,  immunology
Thrombin / administration & dosage,  adverse effects*,  immunology
Reg. No./Substance:
0/Autoantibodies; 0/Hemostatics; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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