| Immune mechanisms in Onchocerca volvulus-mediated corneal disease (river blindness). | |
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MedLine Citation:
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PMID: 11123754 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Infection with the parasitic nematode Onchocerca volvulus can lead to severe visual impairment and blindness. In an effort to characterize the molecular basis for the inflammatory response in the cornea, we have developed a murine model for O. volvulus-mediated keratitis in which parasite antigens are injected into the corneal stroma of sensitized mice. This model reproduces the two main clinical features of human disease, corneal opacification and neovascularization. Histological analysis of corneas from these mice reveals a biphasic recruitment of neutrophils and eosinophils to the central cornea, along with a small, but persistent number of CD3+ cells. In this review, we present evidence that production of antigen-specific T cell and antibody responses are essential for development of O. volvulus keratitis, and we propose a sequence of molecular and cellular events that lead to migration of inflammatory cells to the cornea and to loss of corneal clarity. |
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Authors:
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E Pearlman; L R Hall |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
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Title: Parasite immunology Volume: 22 ISSN: 0141-9838 ISO Abbreviation: Parasite Immunol. Publication Date: 2000 Dec |
Date Detail:
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Created Date: 2001-01-23 Completed Date: 2001-01-26 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7910948 Medline TA: Parasite Immunol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 625-31 Citation Subset: IM |
Affiliation:
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Departments of Medicine and Ophthalmology, Case Western Reserve University, Cleveland, OH, USA. exp2@po.cwru.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antigens, Helminth / immunology Cornea / pathology* Corneal Diseases / immunology*, parasitology, pathology Corneal Opacity / immunology, parasitology, pathology Eosinophils / immunology Keratitis / immunology, parasitology, pathology Neutrophils / immunology Onchocerca volvulus / immunology* Onchocerciasis, Ocular / immunology*, pathology Th2 Cells / immunology |
| Grant Support | |
ID/Acronym/Agency:
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EY06913/EY/NEI NIH HHS; EY10320/EY/NEI NIH HHS; EY11373/EY/NEI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antigens, Helminth |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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