Document Detail

Immune function in sport and exercise.
MedLine Citation:
PMID:  17303714     Owner:  NLM     Status:  MEDLINE    
Regular moderate exercise is associated with a reduced incidence of infection compared with a completely sedentary state. However, prolonged bouts of strenuous exercise cause a temporary depression of various aspects of immune function (e.g., neutrophil respiratory burst, lymphocyte proliferation, monocyte antigen presentation) that usually lasts approximately 3-24 h after exercise, depending on the intensity and duration of the exercise bout. Postexercise immune function dysfunction is most pronounced when the exercise is continuous, prolonged (>1.5 h), of moderate to high intensity (55-75% maximum O(2) uptake), and performed without food intake. Periods of intensified training (overreaching) lasting 1 wk or more may result in longer lasting immune dysfunction. Although elite athletes are not clinically immune deficient, it is possible that the combined effects of small changes in several immune parameters may compromise resistance to common minor illnesses, such as upper respiratory tract infection. However, this may be a small price to pay as the anti-inflammatory effects of exercise mediated through cytokines and/or downregulation of toll-like receptor expression are likely mediators of many of the long-term health benefits of regular exercise.
Michael Gleeson
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Publication Detail:
Type:  Journal Article; Review     Date:  2007-02-15
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  103     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  2007 Aug 
Date Detail:
Created Date:  2007-08-01     Completed Date:  2007-09-20     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  693-9     Citation Subset:  IM    
School of Sport and Exercise Sciences, Loughborough Univ., UK.
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MeSH Terms
Depression / etiology,  immunology
Exercise / physiology*,  psychology
Immune System / physiology*
Inflammation / etiology,  immunology
Pharyngitis / etiology,  immunology
Risk Factors
Sports / physiology*,  psychology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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