Document Detail

Immune function in patients with chronic stable congestive heart failure.
MedLine Citation:
PMID:  8388625     Owner:  NLM     Status:  MEDLINE    
The objective of this study was to ascertain whether immune abnormalities were present in a group of patients with chronic stable heart failure at a time when sympathetic drive was not excessive. Elevated sympathetic tone not only plays an important role in the pathophysiologic characteristics of congestive heart failure but may also regulate certain aspects of immune function, which has been shown to be abnormal in patients with severe heart failure. Studies have indicated a high incidence of heterophil antibodies against constituents of the heart, the presence of antibody-mediated cytotoxicity against cultured heart cells, and a decrease in suppressor and natural killer-cell function in patients with idiopathic dilated cardiomyopathy. Lymphocytes were separated over a Ficoll-Hypaque gradient. Lymphocyte subtypes and well as interleukin-2 receptors were detected by means of mouse monoclonal antibodies conjugated with fluorescein or phycoerytherin, and immunofluorescence was measured with a flow cytometer. Mitogen proliferation was assessed by tritiated thymidine incorporation in the presence of either conconavalin A or tetanus toxoid. Serum was used in conjunction with iodine 125-labeled iodopindolol binding to rat cardiac membranes to attempt to detect beta-receptor antibodies. In patients with ischemic (n = 21) and idiopathic (n = 16) cardiomyopathy, the norepinephrine levels were modestly elevated (idiopathic = 482 +/- 70 pg/ml; ischemic = 501 +/- 45 pg/ml) compared with control subjects without heart disease (n = 10; norepinephrine = 252 +/- 70 pg/ml). We found no differences in the number and subtypes of circulating lymphocytes in the three groups, and there was no serum inhibition of beta-binding to rat cardiac membranes.(ABSTRACT TRUNCATED AT 250 WORDS)
S Hwang; T J Harris; N W Wilson; A S Maisel
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American heart journal     Volume:  125     ISSN:  0002-8703     ISO Abbreviation:  Am. Heart J.     Publication Date:  1993 Jun 
Date Detail:
Created Date:  1993-06-21     Completed Date:  1993-06-21     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370465     Medline TA:  Am Heart J     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1651-8     Citation Subset:  AIM; IM    
Department of Medicine, University of California San Diego.
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MeSH Terms
Chronic Disease
Concanavalin A / immunology
Heart Failure / blood,  immunology*
Leukocyte Count
Lymphocyte Activation
Lymphocytes / chemistry,  physiology
Middle Aged
Receptors, Adrenergic, beta / metabolism
Receptors, Interleukin-2 / analysis
Tetanus Toxoid / immunology
Reg. No./Substance:
0/Receptors, Adrenergic, beta; 0/Receptors, Interleukin-2; 0/Tetanus Toxoid; 11028-71-0/Concanavalin A

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