| Immune evasive mechanisms contributing to persistent Leishmania donovani infection. | |
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MedLine Citation:
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PMID: 20087685 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The protozoan parasite Leishmania donovani, a causative agent of visceral leishmaniasis, has evolved several strategies to interfere with the immune system and establish persistent infections that are potentially lethal. In this article, we discuss two mechanisms of immune evasion adopted by the parasite: the induction of immune suppressive IL-10 responses and the generation of poor and functionally impaired CD8(+) T-cell responses. |
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Authors:
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Simona Stäger; Trupti Joshi; Rashmi Bankoti |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Immunologic research Volume: 47 ISSN: 1559-0755 ISO Abbreviation: Immunol. Res. Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-06-23 Completed Date: 2010-10-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8611087 Medline TA: Immunol Res Country: United States |
Other Details:
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Languages: eng Pagination: 14-24 Citation Subset: IM |
Affiliation:
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Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, BRB, Rm 655, Baltimore, MD 21205, USA. sstager1@jhmi.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals CD8-Positive T-Lymphocytes / immunology Chronic Disease Humans Immune Evasion / immunology* Interleukin-10 / immunology Leishmania donovani / pathogenicity* Leishmaniasis, Visceral / immunology*, parasitology Lymphocyte Activation Mice |
| Chemical | |
Reg. No./Substance:
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130068-27-8/Interleukin-10 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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