| Immune evasion strategies of pediatric precursor-B acute lymphoblastic leukemia after allogeneic bone marrow transplantation-a case study. | |
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MedLine Citation:
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PMID: 15863213 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Bone marrow transplantation (BMT) is the primary curative option for refractory/relapsed pediatric acute lymphoblastic leukemia. Although post-transplantation relapse remains a frequent cause of transplantation failure, the mechanisms underlying this are poorly understood. In this study, we compared allogeneic T cell stimulation induced by sequentially obtained precursor-B acute lymphoblastic leukemia (ALL) samples from a single patient with overt graft versus leukemia (GVL) activity. We observed a loss of T cell stimulatory capacity by post-transplantation relapse samples and changes in expression of MHC and the costimulatory molecule CD137 ligand. This study suggests that escape from immune mechanisms after withdrawal of immune suppression is important to ALL progression. |
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Authors:
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Draga Barbaric; Kristin Wynne; Soudabeh Aslanian; Mason Bond; Gregor S D Reid |
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Publication Detail:
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Type: Case Reports; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Leukemia research Volume: 29 ISSN: 0145-2126 ISO Abbreviation: Leuk. Res. Publication Date: 2005 Jun |
Date Detail:
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Created Date: 2005-05-02 Completed Date: 2005-07-08 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7706787 Medline TA: Leuk Res Country: England |
Other Details:
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Languages: eng Pagination: 711-4 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, Division of Hematology/Oncology/Bone Marrow Transplantation, University of British Columbia and British Columbia's Children's Hospital, Vancouver, BC, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Antigens, CD Antigens, CD137 Bone Marrow Transplantation / adverse effects*, immunology Fatal Outcome Humans Male Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / complications*, diagnosis, immunology* Receptors, Nerve Growth Factor / immunology Receptors, Tumor Necrosis Factor / immunology Recurrence T-Lymphocytes / immunology Tumor Escape / immunology* |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD; 0/Antigens, CD137; 0/Receptors, Nerve Growth Factor; 0/Receptors, Tumor Necrosis Factor; 0/TNFRSF9 protein, human |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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