| Immune evasion strategies of the human gamma-herpesviruses: Implications for viral tumorigenesis. | |
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MedLine Citation:
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PMID: 22170548 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Two human gamma-herpesviruses, Epstein-Barr virus and Kaposi's sarcoma associated herpesvirus/human herpesvirus 8 display oncogenic potential, causing benign and malignant lymphoproliferative disorders in genetically susceptible or immunosuppressed individuals. As a family of viruses that establish persistent life-long infections, herpesviruses have evolved strategies to limit innate antiviral responses and evade host immune surveillance. Herpesviruses have developed mechanisms to disrupt antigen presentation, pirate the production of immune regulating cytokines, and inhibit pro-apoptotic signaling pathways. Although these strategies are designed to facilitate the long-term persistence of herpesviruses, in certain circumstances they can contribute to viral-driven carcinogenesis. J. Med. Virol. 84:272-281, 2012. © 2011 Wiley Periodicals, Inc. |
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Authors:
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Xiangning Zhang; Christopher W Dawson; Zhiwei He; Peichun Huang |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of medical virology Volume: 84 ISSN: 1096-9071 ISO Abbreviation: J. Med. Virol. Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2011-12-15 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7705876 Medline TA: J Med Virol Country: United States |
Other Details:
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Languages: eng Pagination: 272-81 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 Wiley Periodicals, Inc. |
Affiliation:
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Department of Pathophysiology, Guangdong Medical College, Songshan Lake Industrial & Technology Park, Dongguan, Guangdong, China. zhangxn_2006@126.com. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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