Document Detail

Immune enhancement conferred by oral delivery of Lactobacillus rhamnosus HN001 in different milk-based substrates.
MedLine Citation:
PMID:  11928957     Owner:  NLM     Status:  MEDLINE    
The probiotic Lactobacillus rhamnosus HN001 is known to enhance immunity in animal models, following oral delivery. In this study, we investigated the immunoenhancing effects of HN001 delivered to mice in different milk-based substrates, including: whole (full-fat) milk supplemented with HN001; fermented milk supplemented with HN001; or whole milk which had been part-fermented by HN001. Direct oral feeding of mice with HN001 in whole milk was shown to enhance the phagocytic activity of blood and peritoneal cells. Similar effects on phagocytosis were observed when UN001 was offered to mice in the form of a milk- or fermented milk-based diet. The degree of immune enhancement conferred by HN001 was similar whether the probiotic was used as an additive or as a fermentative agent. These studies confirm that Lb. rhamnosus HN001, derived originally from dairy food, enhances immune function following oral delivery in different milk bases.
H S Gill; K J Rutherfurd
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of dairy research     Volume:  68     ISSN:  0022-0299     ISO Abbreviation:  J. Dairy Res.     Publication Date:  2001 Nov 
Date Detail:
Created Date:  2002-04-03     Completed Date:  2002-08-30     Revised Date:  2006-04-13    
Medline Journal Info:
Nlm Unique ID:  2985125R     Medline TA:  J Dairy Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  611-6     Citation Subset:  IM    
Milk & Health Research Centre, Institute of Food, Nutrition and Human Health, Massey University, Palmerston North, New Zealand.
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MeSH Terms
Lactobacillus* / physiology
Mice, Inbred BALB C
Probiotics / administration & dosage*

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