| Immune effects of polychlorinated biphenyls, smoking and alcohol. | |
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MedLine Citation:
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PMID: 23298494 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Polychlorinated biphenyls (PCB) have been shown to exert some immune effects. Here we analysed their effects also on immune parameters not previously studied such as TCR alpha-beta, TCR gamma-delta and regulatory T cells (Treg), taking into account the specific and cumulative interference of smoking and alcohol. The study subjects consisted of 26 male workers in a steelworks factory, employed in the electrical maintenance sector, with previous exposure to a mixture of PCB (exposed subjects), and 30 male workers with no occupational exposure to PCB (controls). All subjects were given a questionnaire and peripheral venous blood samples were taken to determine serum PCB (33 congeners), total cholesterol and triglycerides, leukocytes, total lymphocytes and the T lymphocyte subpopulations (TCR alpha-beta, TCRgamma-delta, CD4+ and Treg lymphocytes). PCB, even though at a very low concentration, were significantly higher in exposed subjects than controls, and were significantly correlated with age. Monocytes% and CD4+ were significantly reduced in the exposed subjects as compared to the controls. The serum concentration of PCB positively correlated with TCR alpha-beta, and negatively with TCRgamma-delta. Treg lymphocytes showed a positive dependence on tobacco smoking, while the monocytes percentage and CD4+ showed a negative and positive dependence, respectively, on alcohol intake. Our results seem to show some effects of slight exposure to PCB in particular reducing the relative concentration of TCRgamma-delta. This effect can favour indirectly the increase in Treg induced by smoking, the anti-inflammatory or proinflammatory/fibrogenetic/angiogenetic effect of which, exerted by produced cytokines, particularly TGF-beta, deserves further clarification. |
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Authors:
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M N D'Errico; G De Tullio; M Di Gioacchino; P Lovreglio; A Basso; I Drago; R Serra; P Apostoli; A Vacca; L Soleo |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: International journal of immunopathology and pharmacology Volume: 25 ISSN: 0394-6320 ISO Abbreviation: Int J Immunopathol Pharmacol Publication Date: 2012 Oct-Dec |
Date Detail:
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Created Date: 2013-01-09 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8911335 Medline TA: Int J Immunopathol Pharmacol Country: Italy |
Other Details:
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Languages: eng Pagination: 1041-54 Citation Subset: IM |
Affiliation:
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Dipartimento Interdisciplinare di Medicina, Sezione di Medicina del Lavoro - E.C. Vigliani -, University of Bari, Bari, Italy. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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