| Immune dysfunction in Down's syndrome: primary immune deficiency or early senescence of the immune system? | |
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MedLine Citation:
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PMID: 8605695 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Multiple immunologic disturbances are commonly observed in individuals with Down's syndrome including abnormal proportions of peripheral blood lymphoid subsets, cellular dysfunction, and autoimmune phenomena. However, a majority of the individuals with this syndrome do not show clear features of immunological disease. Many of these immunological alterations are age-related changes and can be enclosed in the spectrum of multiple signs of early senescence characteristic of Down's syndrome. |
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Authors:
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E Cuadrado; M J Barrena |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Clinical immunology and immunopathology Volume: 78 ISSN: 0090-1229 ISO Abbreviation: Clin. Immunol. Immunopathol. Publication Date: 1996 Mar |
Date Detail:
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Created Date: 1996-05-17 Completed Date: 1996-05-17 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 0356637 Medline TA: Clin Immunol Immunopathol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 209-14 Citation Subset: IM |
Affiliation:
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Sección de Immunología, Hopsital Ntra Sra de Aránzazu, San Sebastián, Spain. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aging
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immunology* Antigens, CD Child Down Syndrome / complications, immunology* Humans Immune System / physiopathology* Lymphocyte Activation Lymphocyte Subsets |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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