| Immune damage to the mesangium: antibody- and complement-mediated stimulation and destruction of mesangial cells. | |
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MedLine Citation:
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PMID: 1600129 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The deposition of immune complexes in the tissue results in complement activation leading to the formation of the lytic C5b-9 complex. Tissue cells are relatively resistant to complement attack due to cellular mechanisms such as removing C5b-9 from the surface and the expression of membrane proteins, which regulate complement activation and attack on the cell surface. Hence, cell killing is not an important consequence of complement activation on nucleated cells. On the other hand, the sublethal C5b-9-membrane interaction leads to various cellular responses, among them the synthesis of eicosanoids, cytokines, matrix-degrading proteases, and extracellular matrix, resulting in the modification of cell proliferation, leukocyte function, matrix degradation, and the formation of scar tissue. Thus, the complement-dependent immune damage is caused by secondary mediators, either derived from leukocytes or mesangial cells, rather than by a direct C5b-9-mediated killing. |
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Authors:
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G M Hänsch; G Schieren; C Wagner; M Schönermark |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Journal of the American Society of Nephrology : JASN Volume: 2 ISSN: 1046-6673 ISO Abbreviation: J. Am. Soc. Nephrol. Publication Date: 1992 Apr |
Date Detail:
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Created Date: 1992-07-15 Completed Date: 1992-07-15 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 9013836 Medline TA: J Am Soc Nephrol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: S139-43 Citation Subset: IM |
Affiliation:
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Institut für Immunologie, University of Heidelberg, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antibodies Complement Activation Complement Membrane Attack Complex Glomerular Mesangium / immunology*, injuries Humans Inflammation / etiology, immunology |
| Chemical | |
Reg. No./Substance:
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0/Antibodies; 0/Complement Membrane Attack Complex |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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