Document Detail


Immune damage to the mesangium: antibody- and complement-mediated stimulation and destruction of mesangial cells.
MedLine Citation:
PMID:  1600129     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The deposition of immune complexes in the tissue results in complement activation leading to the formation of the lytic C5b-9 complex. Tissue cells are relatively resistant to complement attack due to cellular mechanisms such as removing C5b-9 from the surface and the expression of membrane proteins, which regulate complement activation and attack on the cell surface. Hence, cell killing is not an important consequence of complement activation on nucleated cells. On the other hand, the sublethal C5b-9-membrane interaction leads to various cellular responses, among them the synthesis of eicosanoids, cytokines, matrix-degrading proteases, and extracellular matrix, resulting in the modification of cell proliferation, leukocyte function, matrix degradation, and the formation of scar tissue. Thus, the complement-dependent immune damage is caused by secondary mediators, either derived from leukocytes or mesangial cells, rather than by a direct C5b-9-mediated killing.
Authors:
G M Hänsch; G Schieren; C Wagner; M Schönermark
Related Documents :
22783109 - Occurrence of clubroot on shepherd's-purse caused by plasmodiophora brassicae.
132409 - B and t cells in lymphoid tissues of human appendix.
21516529 - Modelling and simulation of substrate elasticity sensing in stem cells.
22901279 - Chromosome breakage and cellular death are induced in oral epitelial cells of hairdress...
3082899 - Urokinase-type and tissue-type plasminogen activators have different distributions in c...
2475259 - A novel monoclonal antibody, 1b3.1, binds to a new epitope of the vla-1 molecule.
10519389 - Decreased sensitivity to 1-o-octadecyl-2-o-methyl-glycerophosphocholine in mcf-7 cells ...
3489099 - Localization of chloride conductance to mitochondria-rich cells in frog skin epithelium.
15752979 - Site selection for the cleavage furrow at cytokinesis.
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of the American Society of Nephrology : JASN     Volume:  2     ISSN:  1046-6673     ISO Abbreviation:  J. Am. Soc. Nephrol.     Publication Date:  1992 Apr 
Date Detail:
Created Date:  1992-07-15     Completed Date:  1992-07-15     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  9013836     Medline TA:  J Am Soc Nephrol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  S139-43     Citation Subset:  IM    
Affiliation:
Institut für Immunologie, University of Heidelberg, Germany.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Antibodies
Complement Activation
Complement Membrane Attack Complex
Glomerular Mesangium / immunology*,  injuries
Humans
Inflammation / etiology,  immunology
Chemical
Reg. No./Substance:
0/Antibodies; 0/Complement Membrane Attack Complex

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Reactive oxygen species as glomerular autacoids.
Next Document:  Morphologic and functional consequences of immune-mediated mesangiolysis: development of chronic glo...