Document Detail

Immune damage to the mesangium: antibody- and complement-mediated stimulation and destruction of mesangial cells.
MedLine Citation:
PMID:  1600129     Owner:  NLM     Status:  MEDLINE    
The deposition of immune complexes in the tissue results in complement activation leading to the formation of the lytic C5b-9 complex. Tissue cells are relatively resistant to complement attack due to cellular mechanisms such as removing C5b-9 from the surface and the expression of membrane proteins, which regulate complement activation and attack on the cell surface. Hence, cell killing is not an important consequence of complement activation on nucleated cells. On the other hand, the sublethal C5b-9-membrane interaction leads to various cellular responses, among them the synthesis of eicosanoids, cytokines, matrix-degrading proteases, and extracellular matrix, resulting in the modification of cell proliferation, leukocyte function, matrix degradation, and the formation of scar tissue. Thus, the complement-dependent immune damage is caused by secondary mediators, either derived from leukocytes or mesangial cells, rather than by a direct C5b-9-mediated killing.
G M Hänsch; G Schieren; C Wagner; M Schönermark
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of the American Society of Nephrology : JASN     Volume:  2     ISSN:  1046-6673     ISO Abbreviation:  J. Am. Soc. Nephrol.     Publication Date:  1992 Apr 
Date Detail:
Created Date:  1992-07-15     Completed Date:  1992-07-15     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  9013836     Medline TA:  J Am Soc Nephrol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  S139-43     Citation Subset:  IM    
Institut für Immunologie, University of Heidelberg, Germany.
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MeSH Terms
Complement Activation
Complement Membrane Attack Complex
Glomerular Mesangium / immunology*,  injuries
Inflammation / etiology,  immunology
Reg. No./Substance:
0/Antibodies; 0/Complement Membrane Attack Complex

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