| Immune cytotoxic mechanism of myocardial lesion in non-specific myocarditis and idiopathic congestive cardiomyopathy. | |
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MedLine Citation:
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PMID: 3391036 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The immune cytotoxic mechanism of myocardial lesion was studied in 15 patients with non-specific myocarditis (NM) and in 10 patients with idiopathic congestive cardiomyopathy (ICC). In addition, 10 control patients having ischaemic heart disease (IHD) with congestive heart failure (CHF) and a control group of blood donors were examined. The following parameters were examined: anti-heart antibodies (by indirect enzyme-linked immunosorbent assay), lymphocyte sensibilization (by leucocyte migration inhibition test; the antigen used was cardiomyocyte membrane protein), and killer cells (K-cells) activity in the course of antibody-dependent cell-mediated cytotoxicity. Anti-heart antibodies were found in 73% of patients with NM, 50% patients with ICC and 33% patients with CHF. Lymphocyte sensibilization to the myocardium was found in 87% of patients with NM, and in more than half of the patients with ICC. Cardiospecific cytotoxic immune reaction was reproduced in vitro in 9 patients with NM and in 4 patients with ICC. It is assumed that an analogical mechanism of myocardial lesion functions in vivo. |
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Authors:
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Zimin YuI; A V Sumarokov; S E Tereshchenko |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Cor et vasa Volume: 30 ISSN: 0010-8650 ISO Abbreviation: Cor Vasa Publication Date: 1988 |
Date Detail:
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Created Date: 1988-08-19 Completed Date: 1988-08-19 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0372614 Medline TA: Cor Vasa Country: CZECHOSLOVAKIA |
Other Details:
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Languages: eng Pagination: 127-34 Citation Subset: IM |
Affiliation:
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Laboratory of Clinical Immunology, Central Research Laboratory of the USSR Ministry of Public Health, Moscow. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Autoantibodies / immunology Cardiomyopathy, Dilated / immunology* Cytotoxicity, Immunologic* Enzyme-Linked Immunosorbent Assay Female Humans Killer Cells, Natural / immunology Male Middle Aged Myocarditis / immunology* Myocardium / immunology* |
| Chemical | |
Reg. No./Substance:
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0/Autoantibodies |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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