Document Detail

Immune control of HSV-1 latency.
MedLine Citation:
PMID:  16212525     Owner:  NLM     Status:  MEDLINE    
A hallmark of the herpes family of viruses is their ability to cause recurrent disease. Upon primary infection, Herpes Simplex virus (HSV) establishes a latent infection in sensory neurons that persists for the life of the individual. Reactivation of these latent viral genomes with virion formation is the source of virus for most HSV recurrent disease. This review details recent exciting findings supporting a role for the host immune system, particularly CD8+ T cells in maintaining HSV-1 in a latent state.
Vilma Decman; Michael L Freeman; Paul R Kinchington; Robert L Hendricks
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Viral immunology     Volume:  18     ISSN:  0882-8245     ISO Abbreviation:  Viral Immunol.     Publication Date:  2005  
Date Detail:
Created Date:  2005-10-10     Completed Date:  2005-12-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8801552     Medline TA:  Viral Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  466-73     Citation Subset:  IM    
Department of Ophthalmology, Graduate Programs in Immunology, University of Pittsburgh School of Medicine, 203 Lothrop Street, Pittsburgh, PA 15213, USA.
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MeSH Terms
CD8-Positive T-Lymphocytes / immunology,  virology
Gene Expression
Herpes Simplex / immunology,  virology
Herpesvirus 1, Human / genetics,  immunology*,  pathogenicity,  physiology
Histocompatibility Antigens Class I / metabolism
Neurons / immunology,  virology
Virus Latency / immunology
Reg. No./Substance:
0/Histocompatibility Antigens Class I

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