Document Detail


Immune control of HSV-1 latency.
MedLine Citation:
PMID:  16212525     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A hallmark of the herpes family of viruses is their ability to cause recurrent disease. Upon primary infection, Herpes Simplex virus (HSV) establishes a latent infection in sensory neurons that persists for the life of the individual. Reactivation of these latent viral genomes with virion formation is the source of virus for most HSV recurrent disease. This review details recent exciting findings supporting a role for the host immune system, particularly CD8+ T cells in maintaining HSV-1 in a latent state.
Authors:
Vilma Decman; Michael L Freeman; Paul R Kinchington; Robert L Hendricks
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Viral immunology     Volume:  18     ISSN:  0882-8245     ISO Abbreviation:  Viral Immunol.     Publication Date:  2005  
Date Detail:
Created Date:  2005-10-10     Completed Date:  2005-12-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8801552     Medline TA:  Viral Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  466-73     Citation Subset:  IM    
Affiliation:
Department of Ophthalmology, Graduate Programs in Immunology, University of Pittsburgh School of Medicine, 203 Lothrop Street, Pittsburgh, PA 15213, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
CD8-Positive T-Lymphocytes / immunology,  virology
Gene Expression
Herpes Simplex / immunology,  virology
Herpesvirus 1, Human / genetics,  immunology*,  pathogenicity,  physiology
Histocompatibility Antigens Class I / metabolism
Humans
Mice
Neurons / immunology,  virology
Recurrence
Virus Latency / immunology
Chemical
Reg. No./Substance:
0/Histocompatibility Antigens Class I

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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