Document Detail

Immune complexes as therapy for autoimmunity.
MedLine Citation:
PMID:  15630438     Owner:  NLM     Status:  MEDLINE    
For several decades, intravenous Ig has been used as treatment for a variety of immune-related diseases, including immune thrombocytopenic purpura (ITP), autoimmune neuropathies, systemic lupus erythematosus, myasthenia gravis, Guillain-Barré syndrome, skin blistering syndromes, and Kawasaki disease. Despite years of use, its mechanism of immunomodulation is still unclear. Recent studies using mouse models of ITP and arthritis, including one reported in this issue of the JCI, now provide some insights into this mechanism and the rationale for the development of Fcgamma receptor-targeted therapeutics.
Raphael Clynes
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Publication Detail:
Type:  Comment; Journal Article    
Journal Detail:
Title:  The Journal of clinical investigation     Volume:  115     ISSN:  0021-9738     ISO Abbreviation:  J. Clin. Invest.     Publication Date:  2005 Jan 
Date Detail:
Created Date:  2005-01-04     Completed Date:  2005-02-10     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7802877     Medline TA:  J Clin Invest     Country:  United States    
Other Details:
Languages:  eng     Pagination:  25-7     Citation Subset:  AIM; IM    
Department of Medicine and Microbiology, Columbia University, New York, New York 10032, USA.
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MeSH Terms
Antigen-Antibody Complex / immunology*
Autoimmunity / immunology*
Immunoglobulins, Intravenous / immunology
Purpura, Thrombocytopenic, Idiopathic / immunology*,  pathology,  therapy*
Receptors, Fc / immunology
Rho(D) Immune Globulin / immunology
Reg. No./Substance:
0/Antigen-Antibody Complex; 0/Immunoglobulins, Intravenous; 0/Receptors, Fc; 0/Rho(D) Immune Globulin
Comment On:
J Clin Invest. 2005 Jan;115(1):155-60   [PMID:  15630455 ]

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