Document Detail

Immune complex levels and HBs-antigenaemia in healthy Nigerians and patients with liver diseases.
MedLine Citation:
PMID:  1308079     Owner:  NLM     Status:  MEDLINE    
Circulating immune complexes (CIC) were precipitated and assayed in the blood of 19 adult patients with liver diseases and 39 healthy adult Nigerians. The presence of hepatitis-Bs antigen (HBs-Ag) was also investigated in both the sera and CIC of both study groups. CIC levels were not significantly different in the three different liver diseases studied (acute hepatitis, chronic hepatitis and liver cirrhosis). Higher mean CIC levels which were not correlated with the presence of HBs-Ag, were found in the blood of patients, as compared to blood donors. While HBs- Ag was detected in 42.1% of patient's sera, only 12.8% of blood donor sera had detectable antigen. However, 42.1% of CIC from patients had the antigen, while 53.8% of CIC from blood donors also contained the antigen. It is suggested that the high frequency of HBs-Ag in the precipitated CIC of healthy subjects could account for the occurrence of some post-transfusion hepatitis-B infections.
A A Okerengwo; M A Atoba
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  African journal of medicine and medical sciences     Volume:  21     ISSN:  0309-3913     ISO Abbreviation:  Afr J Med Med Sci     Publication Date:  1992 Dec 
Date Detail:
Created Date:  1993-09-23     Completed Date:  1993-09-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7801013     Medline TA:  Afr J Med Med Sci     Country:  NIGERIA    
Other Details:
Languages:  eng     Pagination:  35-8     Citation Subset:  IM    
Postgraduate Institute for Medical Research and Training, University of Ibadan, Nigeria.
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MeSH Terms
Acute Disease
Antigen-Antibody Complex / analysis,  blood*
Blood Donors
Blood Transfusion
Chronic Disease
Hepatitis / blood*
Hepatitis B Surface Antigens / analysis,  blood*
Liver Cirrhosis / blood*
Middle Aged
Reg. No./Substance:
0/Antigen-Antibody Complex; 0/Hepatitis B Surface Antigens

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