Document Detail

Immune and clinical impact of Lactobacillus acidophilus on asthma.
MedLine Citation:
PMID:  9305229     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Animal and human studies have suggested that yogurt containing live active bacteria leads to improved immune and clinical responses. Specific benefits of yogurt containing L. acidophilus on allergic asthma have been hypothesized but not studied. METHODS: In a crossover double-blinded design, the effect of live active yogurt (225 g twice daily) with or without L. acidophilus was studied in 15 adult patients with moderate asthma. Immune and clinical parameters were measured before and after the two 1-month crossover phases. RESULTS: No significant changes were noted in peripheral cell counts, IgE, IL-2, or IL-4 when comparing the two diets to each other. Concanvalin A-stimulated lymphocytes from patients who consumed yogurt containing L. acidophilus produced borderline elevated interferon gamma levels (P = .054). No differences were noted in mean daily peak flows or changes in spirometric values. Quality of life indices were unchanged when comparing the two groups. CONCLUSIONS: Yogurt containing L. acidophilus generated trends in the increase in interferon gamma and decreased eosinophilia; however, we were unable to detect changes in clinical parameters in asthma patients in association with these modest immune changes.
J G Wheeler; S J Shema; M L Bogle; M A Shirrell; A W Burks; A Pittler; R M Helm
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology     Volume:  79     ISSN:  1081-1206     ISO Abbreviation:  Ann. Allergy Asthma Immunol.     Publication Date:  1997 Sep 
Date Detail:
Created Date:  1997-10-06     Completed Date:  1997-10-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9503580     Medline TA:  Ann Allergy Asthma Immunol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  229-33     Citation Subset:  IM    
Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, USA.
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MeSH Terms
Antibodies, Bacterial / pharmacology
Asthma / immunology*
Cross-Over Studies
Double-Blind Method
Lactobacillus acidophilus / immunology*,  isolation & purification
Middle Aged
Nutritional Status
Quality of Life
Respiratory Function Tests
Yogurt / microbiology
Reg. No./Substance:
0/Antibodies, Bacterial

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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