| Immune cell membrane fatty acids and inflammatory marker, C-reactive protein, in patients with multiple sclerosis. | |
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MedLine Citation:
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PMID: 19454128 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Measurement of fatty acids in biological fluids and cell membranes including leucocytes from multiple sclerosis patients is inconsistent. The objective of the present study was to investigate the fatty acid composition within the different membrane phospholipid fractions in peripheral blood mononuclear cells in multiple sclerosis patients, and correlate with severity of neurological outcome as measured by the Kurtzke Expanded Disability Status Scale and Functional System Scores. The fatty acid composition of phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, sphingomyelin and phosphatidylinositol phospholipids in the peripheral blood mononuclear cells of twenty-six multiple sclerosis and twenty-five control subjects were measured by GC, and C-reactive protein was measured in all subjects. The elongation product of 20 : 4n-6, 22 : 4n-6, was significantly decreased in membrane phosphatidylethanolamine and phosphatidylserine in multiple sclerosis patients (P = 0.01 and P = 0.03 respectively), and correlated inversely with severity of disease and C-reactive protein. Also an inverse correlation was observed between the C-reactive protein and membrane phosphatidylcholine and phosphatidylserine 20 : 4n-6. Cultural and ethnic differences, as well as dietary variability, especially in a diseased state have been implicated in the differences observed in the fatty acid composition in peripheral blood mononuclear cell membranes of patients with multiple sclerosis. The present results suggest that the disease state may in part explain the reported inconsistencies in fatty acid levels in multiple sclerosis patients. |
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Authors:
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Gloudina Hon; Mogamat Hassan; Susan Janse van Rensburg; Stefan Abel; De Wet Marais; Paul van Jaarsveld; Cornelius Smuts; Franclo Henning; Rajiv Erasmus; Tandi Matsha |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-05-19 |
Journal Detail:
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Title: The British journal of nutrition Volume: 102 ISSN: 1475-2662 ISO Abbreviation: Br. J. Nutr. Publication Date: 2009 Nov |
Date Detail:
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Created Date: 2009-10-30 Completed Date: 2009-12-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372547 Medline TA: Br J Nutr Country: England |
Other Details:
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Languages: eng Pagination: 1334-40 Citation Subset: IM |
Affiliation:
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Department of Biomedical Technology, Faculty of Health and Wellness Science, Cape Peninsula University of Technology, Cape Town, South Africa. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Biological Markers / blood Blood Specimen Collection / methods C-Reactive Protein / metabolism* Disability Evaluation Fatty Acids / blood* Fatty Acids, Omega-3 / blood Fatty Acids, Omega-6 / blood Female Humans Inflammation Mediators / blood* Leukocytes, Mononuclear / metabolism* Male Membrane Lipids / blood Middle Aged Multiple Sclerosis, Relapsing-Remitting / blood* Severity of Illness Index |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Fatty Acids; 0/Fatty Acids, Omega-3; 0/Fatty Acids, Omega-6; 0/Inflammation Mediators; 0/Membrane Lipids; 9007-41-4/C-Reactive Protein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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