| Immune cell NT-3 expression is associated with brain atrophy in multiple sclerosis patients. | |
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MedLine Citation:
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PMID: 22036954 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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While neurotrophins mediate cell survival and proliferation in the nervous system, they are also expressed within peripheral blood mononuclear cells (PBMCs) of the immunological system. In multiple sclerosis (MS) neurotrophins released from PBMCs might play a neuroprotective role, delaying neurodegeneration within central nervous system. We aimed for identifying the link between neurotrophins' PBMCs expression and brain atrophy markers in relapsing-remitting MS (RRMS) patients. We have found that neurotrophin-3 PBMCs concentration is strongly correlated with brain-parenchymal fraction and corpus callosum cross-sectional area, which are well-established brain atrophy measures. Thus, PBMC-derived neurotrophin-3 might exert a direct or indirect neuroprotective effect in MS. |
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Authors:
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Alicja Kalinowska-Łyszczarz; Mikołaj A Pawlak; Sławomir Michalak; Włodzimierz Paprzycki; Jacek Losy |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-10-28 |
Journal Detail:
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Title: Journal of neuroimmunology Volume: - ISSN: 1872-8421 ISO Abbreviation: - Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-10-31 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8109498 Medline TA: J Neuroimmunol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011. Published by Elsevier B.V. |
Affiliation:
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Department of Clinical Neuroimmunology, Chair of Neurology, Poznan University of Medical Sciences, Przybyszewskiego 49, 60-355 Poznan, Poland. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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