| The immune system in pregnancy: a unique complexity. | |
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MedLine Citation:
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PMID: 20367629 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Placental immune response and its tropism for specific viruses and pathogens affect the outcome of the pregnant woman's susceptibility to and severity of certain infectious diseases. The generalization of pregnancy as a condition of immune suppression or increased risk is misleading and prevents the determination of adequate guidelines for treating pregnant women during pandemics. There is a need to evaluate the interaction of each specific pathogen with the fetal/placental unit and its responses to design the adequate prophylaxis or therapy. The complexity of the immunology of pregnancy and the focus, for many years, on the concept of immunology of pregnancy as an organ transplantation have complicated the field and delayed the development of new guidelines with clinical implications that could help to answer these and other relevant questions. Our challenge as scientists and clinicians interested in the field of reproductive immunology is to evaluate many of the 'classical concepts' to define new approaches for a better understanding of the immunology of pregnancy that will benefit mothers and fetuses in different clinical scenarios. |
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Authors:
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Gil Mor; Ingrid Cardenas |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Review Date: 2010-03-29 |
Journal Detail:
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Title: American journal of reproductive immunology (New York, N.Y. : 1989) Volume: 63 ISSN: 1600-0897 ISO Abbreviation: Am. J. Reprod. Immunol. Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-06-22 Completed Date: 2010-10-14 Revised Date: 2011-07-20 |
Medline Journal Info:
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Nlm Unique ID: 8912860 Medline TA: Am J Reprod Immunol Country: Denmark |
Other Details:
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Languages: eng Pagination: 425-33 Citation Subset: IM |
Affiliation:
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Department of Obstetrics, Gynecology and Reproductive Sciences, Reproductive Immunology Unit, School of Medicine, Yale University, New Haven, CT 06520, USA. gil.mor@yale.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Female Humans Immune System* Placenta / immunology, virology Pregnancy / immunology* Pregnancy Complications, Infectious / immunology, virology Virus Diseases / immunology, transmission, virology |
| Grant Support | |
ID/Acronym/Agency:
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3N01 HD23342/HD/NICHD NIH HHS; P01 HD054713-03/HD/NICHD NIH HHS; P01HD054713/HD/NICHD NIH HHS |
| Comments/Corrections | |
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