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Immune Pathogenesis of Asymptomatic Chlamydia trachomatis Infections in the Female Genital Tract.
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MedLine Citation:
PMID:  18476043     Owner:  NLM     Status:  In-Data-Review    
Chlamydia trachomatis (CT) infections of the female genital tract, although frequently asymptomatic, are a major cause of fallopian-tube occlusion and infertility. Early stage pregnancy loss may also be due to an unsuspected and undetected CT infection. In vitro and in vivo studies have demonstrated that this organism can persist in the female genital tract in a form undetectable by culture. The mechanism of tubal damage as well as the rejection of an embryo may involve an initial immune sensitization to the CT 60 kD heat shock protein (HSP), followed by a reactivation of HSP-sensitized lymphocytes in response to the human HSP and the subsequent release of inflammatory cytokines. The periodic induction of human HSP expression by various microorganisms or by noninfectious mechanisms in the fallopian tubes of women sensitized to the CT HSP may eventually result in tubal scarring and occlusion. Similarly, an immune response to human HSP expression during the early stages of pregnancy may interfere with the immune regulatory mechanisms required for the maintenance of a semiallogeneic embryo.
S S Witkin
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Infectious diseases in obstetrics and gynecology     Volume:  3     ISSN:  1064-7449     ISO Abbreviation:  Infect Dis Obstet Gynecol     Publication Date:  1995  
Date Detail:
Created Date:  2008-05-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9318481     Medline TA:  Infect Dis Obstet Gynecol     Country:  Egypt    
Other Details:
Languages:  eng     Pagination:  169-74     Citation Subset:  -    
Division of Immunology and Infectious Diseases Department of Obstetrics and Gynecology Cornell University Medical College 515 East 71 Street New York 10021 USA.
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Journal Information
Journal ID (nlm-ta): Infect Dis Obstet Gynecol
ISSN: 1064-7449
ISSN: 1098-0997
Publisher: Hindawi Publishing Corporation
Article Information
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Copyright ? 1995 Hindawi Publishing Corporation.
open-access: This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Received Day: 8 Month: 6 Year: 1995
Accepted Day: 14 Month: 9 Year: 1995
Print publication date: Year: 1995
Volume: 3 Issue: 4
First Page: 169 Last Page: 174
ID: 2364440
PubMed Id: 18476043
Publisher Item Identifier: S1064744995000548
DOI: 10.1155/S1064744995000548

Immune Pathogenesis of Asymptomatic Chlamydia trachomatis Infections in the Female Genital Tract
Steven S. Witkin
Division of Immunology and Infectious DiseasesDepartment of Obstetrics and GynecologyCornell University Medical College515 East 71 StreetNew York10021USA

Article Categories:
  • Research Article

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