Document Detail


Immune-Mediated Diseases and Immunodeficiencies Associated with Thymic Epithelial Neoplasms.
MedLine Citation:
PMID:  22228568     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
INTRODUCTION: This retrospective study aimed to characterize the clinical hematological and immunological features of patients with thymic epithelial neoplasms. METHODS: From a cohort of 512 patients with thymic epithelial neoplasms, 79 patients diagnosed with autoimmune/immunodeficiency conditions or signs and/or symptoms suggesting an autoimmune or immunodeficiency state were evaluated by standard immunological and hematological testing. RESULTS: Elevated percentages of CD2+, CD3+, and CD8+ lymphocytes were observed in 44 (57.1%), 33 (41.8%), and 32 (40.5%) patients. Low CD4+ and CD19+ percentages were observed in 25 (31.6%) and 36 (46.2%), respectively; CD4+:CD8+ ratios were inverted in 18 (22.8%). IgG, IgA, and IgM levels were low in 12 (15.8%), 9 (11.7%) and 15 (19.7%) patients, respectively. Patients with immunodeficiency condition(s) were more likely to have high CD8+ percentages (p = 0.040), low CD19+ percentages (p = 0.025), and/or inverted CD4+/CD8+ ratios (p = 0.034). Patients with autoimmune condition(s) were more likely to have a high/normal CD4+ percentage (p = 0.038). High CD2+ percentages were associated with lower mean IgG and IgA levels (p = 0.030 and p = 0.017, respectively). High CD3+ and CD8+ percentages were associated with lower mean IgA levels (p = 0.046 and p = 0.013, respectively). Low CD19+ percentages were associated with lower mean IgG and IgA levels (p = 0.004 and p < 0.001, respectively). CONCLUSION: Signs/symptoms and history of autoimmune and immunodeficiency conditions among patients with thymic epithelial neoplasms are associated with high frequencies of abnormalities in immunoglobulin levels and lymphocyte immunophenotypes, suggesting a role for their assessment.
Authors:
Muhammad Rizwan Khawaja; Robert P Nelson; Nicholas Miller; Sunil S Badve; Elizabeth Loehrer; Magdalena Czader; Susan M Perkins; Kenneth Kesler; Patrick J Loehrer
Related Documents :
17541218 - Significance of serum uric acid in patients with chronic respiratory failure treated wi...
15902528 - Synovial nitric oxide concentrations are increased and correlated with serum levels in ...
22899938 - Clinical and pathological features of childhood-onset nemaline myopathy: a report of fo...
8449558 - Serum lactate dehydrogenase in head and neck malignancy patients.
9339688 - Genetic testing of children at risk for huntington's disease. us huntington disease gen...
19521678 - Altered reward functions in patients on atypical antipsychotic medication in line with ...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-1-8
Journal Detail:
Title:  Journal of clinical immunology     Volume:  -     ISSN:  1573-2592     ISO Abbreviation:  -     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-1-9     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8102137     Medline TA:  J Clin Immunol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Clinical and Genetic Characteristics of XIAP Deficiency in Japan.
Next Document:  Subcutaneous Immunoglobulin Replacement Therapy with Hizentra® is Safe and Effective in Two Infants...