Document Detail


Immune interventions of human diseases through toll-like receptors.
MedLine Citation:
PMID:  20047036     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Toll-like receptors (TLRs) are the immune sensors for infections, triggering robust innate immune activation followed by protective adaptive immunity against various infectious diseases. Recent evidence, however, has suggested that TLRs are involved in the pathogenesis of many diseases, including not only infectious diseases but also autoimmune diseases, allergy and atherosclerosis. Therefore, prophylactic or therapeutic application of TLR-based immune interventions should be potent, but their safety must be demonstrated using experimental animal models as well as human resources, including analysis of single nucleotide polymorphisms. Here, we focus on recent advances in understanding of the protective and pathogenic roles of TLRs in human diseases.
Authors:
Cevayir Coban; Ken J Ishii; Shizuo Akira
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Advances in experimental medicine and biology     Volume:  655     ISSN:  0065-2598     ISO Abbreviation:  Adv. Exp. Med. Biol.     Publication Date:  2009  
Date Detail:
Created Date:  2010-01-04     Completed Date:  2010-08-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0121103     Medline TA:  Adv Exp Med Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  63-80     Citation Subset:  IM    
Affiliation:
Department of Host Defense and 21st Century COE Program Research Institute for Microbial Diseases, Osaka University, 3-1 Yamada-oka, Suita, Osaka, 565-0871, Japan.
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MeSH Terms
Descriptor/Qualifier:
Animals
Atherosclerosis / drug therapy,  immunology
Autoimmune Diseases / drug therapy,  immunology*
Drosophila melanogaster
Humans
Hypersensitivity / drug therapy,  immunology
Immune System
Ligands
Models, Biological
Polymorphism, Single Nucleotide
Signal Transduction
Toll-Like Receptors / metabolism*
Chemical
Reg. No./Substance:
0/Ligands; 0/Toll-Like Receptors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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