| Immune evasion and counteraction of restriction factors by HIV-1 and other primate lentiviruses. | |
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MedLine Citation:
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PMID: 20638642 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Retroviruses have evolved effective strategies to evade the host immune response, such as high variability and latent infection. In addition, primate lentiviruses, such as HIV-1, have acquired several "accessory" genes that antagonize antiviral host restriction factors and facilitate viral immune evasion, thereby allowing continuous and efficient viral replication despite apparently strong innate and acquired immune responses. Here, I summarize some of our current knowledge on the acquisition and function of the viral vif, vpr, vpu, and nef genes, with a particular focus on the evolution and specific properties of pandemic HIV-1 strains that may contribute to their efficient spread and high virulence. |
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Authors:
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Frank Kirchhoff |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Cell host & microbe Volume: 8 ISSN: 1934-6069 ISO Abbreviation: Cell Host Microbe Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-07-19 Completed Date: 2010-10-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101302316 Medline TA: Cell Host Microbe Country: United States |
Other Details:
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Languages: eng Pagination: 55-67 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Institute of Molecular Virology, University Hospital Ulm, Meyerhofstrasse 1, 89081 Ulm, Germany. frank.kirchhoff@uni-ulm.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals HIV Infections / immunology*, virology HIV-1 / immunology*, pathogenicity, physiology Host-Pathogen Interactions* Humans Immune Evasion* Lentivirus Infections / immunology*, virology Lentiviruses, Primate / immunology*, pathogenicity, physiology Viral Proteins / genetics, immunology |
| Chemical | |
Reg. No./Substance:
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0/Viral Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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