Document Detail


Immortalized human microglial cell line: phenotypic expression.
MedLine Citation:
PMID:  15957187     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Microglia are a major neuroglial component of the CNS, playing an important role as resident immunocompetent and phagocytic cells in the CNS in the event of injury and disease. To understand the role of microglia in the CNS in health and diseases, we have recently established an immortalized clonal cell line of human microglia, HMO6, from human embryonic telencephalon tissue by using a retroviral vector encoding v-myc. This immortalized microglia HMO6 cell line exhibits cell-type-specific antigens for microglia, including CD11b (Mac-1), CD68, CD86 (B7-2), HLA-ABC, HLA-DR, and RCA-1 lectin, and actively phagocytoses latex beads.
Authors:
Atsushi Nagai; Seiji Mishima; Yuri Ishida; Hiroto Ishikura; Takayuki Harada; Shotai Kobayashi; Seung U Kim
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Journal of neuroscience research     Volume:  81     ISSN:  0360-4012     ISO Abbreviation:  J. Neurosci. Res.     Publication Date:  2005 Aug 
Date Detail:
Created Date:  2005-08-01     Completed Date:  2005-11-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7600111     Medline TA:  J Neurosci Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  342-8     Citation Subset:  IM    
Copyright Information:
(c) 2005 Wiley-Liss, Inc.
Affiliation:
Department of Neurology, Shimane University School of Medicine, Izumo, Japan.
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MeSH Terms
Descriptor/Qualifier:
Animals
Antigen-Presenting Cells / metabolism
Cell Line
Cell Transplantation
Chemokines / metabolism
Cytokines / metabolism
Gene Expression Regulation / physiology*
Humans
Mice
Microglia / cytology*,  physiology
Phenotype*
Chemical
Reg. No./Substance:
0/Chemokines; 0/Cytokines

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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