Document Detail


Immobilizing doses of halothane, isoflurane or propofol, do not preferentially depress noxious heat-evoked responses of rat lumbar dorsal horn neurons with ascending projections.
MedLine Citation:
PMID:  18292450     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The spinal cord is an important site where volatile anesthetics decrease sensation and produce immobility. Beyond this knowledge, our understanding of a site of anesthetic action is limited. Previous evidence suggests that dorsal horn neurons with ascending projections may be more susceptible to depression by general anesthetics than local spinal interneurons. In this study we evaluated the effects of volatile and injectable general anesthetics on lumbar dorsal horn neurons with and without ascending projections.
METHODS: Thirty-seven adult male rats underwent laminectomies at C1, for placement of a stimulating electrode, and T13/L1, for extracellular recording from the spinal cord dorsal horn. Neuronal responses to heat were evaluated under two doses of halothane, isoflurane, or propofol anesthesia.
RESULTS: Under both halothane and isoflurane anesthesia, increasing the dose from 0.8 to 1.2 minimum alveolar concentration (MAC) had no significant effect on heat-evoked responses in neurons that had ascending projections identified via antidromic stimulation (AD) or those without ascending projections (nAD). Heat responses in AD neurons 1 min after i.v. administration of 3 and 5 mg/kg of propofol were reduced to 60% +/- 18% (mean +/- SE) and 39% +/- 14% of control respectively. Similarly, in nAD neurons responses were reduced to 56% +/- 14% and 50% +/- 10% of control by 3 and 5 mg/kg propofol respectively.
CONCLUSIONS: Our findings suggest, at peri-MAC concentrations, these general anesthetics do not preferentially depress lumbar dorsal horn neurons with ascending projections compared to those with no identifiable ascending projections.
Authors:
Linda S Barter; Laurie O Mark; Steven L Jinks; Earl E Carstens; Joseph F Antognini
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Anesthesia and analgesia     Volume:  106     ISSN:  1526-7598     ISO Abbreviation:  Anesth. Analg.     Publication Date:  2008 Mar 
Date Detail:
Created Date:  2008-02-22     Completed Date:  2008-03-11     Revised Date:  2011-08-01    
Medline Journal Info:
Nlm Unique ID:  1310650     Medline TA:  Anesth Analg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  985-90, table of contents     Citation Subset:  AIM; IM    
Affiliation:
Department of Anesthesiology and Pain Medicine, University of California, Davis, California, USA. lsbarter@ucdavis.edu
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MeSH Terms
Descriptor/Qualifier:
Anesthetics, Inhalation / pharmacology*
Anesthetics, Intravenous / pharmacology*
Animals
Dose-Response Relationship, Drug
Electric Stimulation
Evoked Potentials / drug effects*
Halothane / pharmacology*
Hot Temperature*
Immobilization
Isoflurane / pharmacology*
Laminectomy
Male
Movement / drug effects
Neural Conduction / drug effects
Posterior Horn Cells / drug effects*
Propofol / pharmacology*
Rats
Rats, Sprague-Dawley
Time Factors
Visceral Afferents / drug effects*
Grant Support
ID/Acronym/Agency:
GM 61283/GM/NIGMS NIH HHS; R01 GM078167-01/GM/NIGMS NIH HHS; R01 GM078167-02/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Anesthetics, Inhalation; 0/Anesthetics, Intravenous; 151-67-7/Halothane; 2078-54-8/Propofol; 26675-46-7/Isoflurane
Comments/Corrections

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