Document Detail

Immobilization of polysaccharides on a fluorinated silicon surface.
MedLine Citation:
PMID:  16387479     Owner:  NLM     Status:  MEDLINE    
A self-assembled monolayer (SAM) of fluoroalkyl silane (FAS) was deposited on a silicon surface by chemical vapor deposition (CVD) at room temperature under 1.01x10(5)Pa nitrogen. Using this new approach, the quality and reproducibility of the SAM are better than those prepared either in solution or by vapor phase deposition, and the deposition process is simpler. In this modified CVD process, the silane monomers, instead of the oligomeric species, are the primary reactants. Full coverage of the silicon surface by FAS molecules was achieved within 5 min. Heparin and hyaluronan, two naturally occurring biocompatible polysaccharides, were successfully covalently attached on the FAS SAM/Si surface by photo-immobilization. Atomic force microscopy (AFM) revealed the morphologic changes after the immobilization of heparin and hyaluronan, and X-ray photoelectron spectroscopy (XPS) confirmed the change in chemical compositions. Such combination of coatings is expected to enhance the stability and biocompatibility of the base material.
Anfeng Wang; Ting Cao; Haiying Tang; Xuemei Liang; Carolyn Black; Steven O Salley; James P McAllister; Gregory W Auner; K Y Simon Ng
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Colloids and surfaces. B, Biointerfaces     Volume:  47     ISSN:  0927-7765     ISO Abbreviation:  Colloids Surf B Biointerfaces     Publication Date:  2006 Jan 
Date Detail:
Created Date:  2006-01-23     Completed Date:  2006-04-17     Revised Date:  2009-10-16    
Medline Journal Info:
Nlm Unique ID:  9315133     Medline TA:  Colloids Surf B Biointerfaces     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  57-63     Citation Subset:  IM    
Department of Chemical Engineering and Materials Science, Wayne State University, 5050 Anthony Wayne Drive, Detroit, MI 48202, USA.
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MeSH Terms
Biocompatible Materials / chemistry*
Fluorine / chemistry*
Heparin / chemistry*
Hyaluronic Acid / chemistry*
Microscopy, Atomic Force
Silanes / chemistry*
Silicon / chemistry*
Surface Properties
Reg. No./Substance:
0/Biocompatible Materials; 0/Silanes; 7440-21-3/Silicon; 7782-41-4/Fluorine; 9004-61-9/Hyaluronic Acid; 9005-49-6/Heparin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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