Document Detail

Immobilisation increases interleukin-6, but not tumor necrosis factor-α, release from the leg during exercise in humans.
MedLine Citation:
PMID:  23143992     Owner:  NLM     Status:  Publisher    
Data on interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) release during acute exercise are not conclusive and lack information about the impact of physical inactivity. Some studies have shown an increase, but others report no changes in IL-6 and TNF-α release during exercise. We have now studied the temporal relationship of leg IL-6 and TNF-α release before and during isolated two legged exercise after 14 days of one leg immobilization (IM) while the other served as control (CON) leg. Fifteen healthy male subjects (age 23±1 (mean±SEM) yr; BMI 23.6±0.7 kg m-2; VO2max 46.8±1.4 ml kg-1 min-1) performed 45 min of two leg dynamic knee-extensor exercise at (19.6±0.8 W). Arterial (A) and femoral venous blood samples from the CON and the IM leg were collected every 15 minutes during exercise, and leg blood flow was measured with ultrasound Doppler. The arterial plasma IL-6 concentration increased (P<0.05) with exercise (rest: 1.3±0.1, 15 min: 1.9±0.2; 30 min: 2.4±0.2 and 45 min: 3.1±0.3 pg ml-1. IL-6 release occurred after 15 min of exercise and the release from the IM leg was significantly higher compared with the CON leg after 45 min (1114±152 vs. 606±14 pg min-1, respectively, P<0.05). TNF-α release did not differ between the CON and the IM leg and arterial concentrations remained unchanged during exercise (P>0.05). Conclusion: Prior immobilization enhances leg IL-6 release during exercise at a moderate workload and the release is present already in the early phase of exercise. Neither immobilization, nor exercise had an effect on TNF-α release across the working legs.
Dace Reihmane; Andreas Vigelsø Hansen; Martin Gram; Anja Birk Kuhlman; Jesper Nørregaard; Helene Pape Pedersen; Michael T Lund; Jørn Wulff Helge; Flemming Dela
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-9
Journal Detail:
Title:  Experimental physiology     Volume:  -     ISSN:  1469-445X     ISO Abbreviation:  Exp. Physiol.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9002940     Medline TA:  Exp Physiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
1 University of Latvia;
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