| Immediate-type allergy against insulin itself: clinical and immunologic studies on a diabetic patient with insulin intolerance. | |
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MedLine Citation:
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PMID: 7011726 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In this report clinical and immunologic data of a female diabetic patient with immediate-type allergy against insulin preparations of different species, including pancreatic human insulin, biosynthetic human insulin and semisynthetic human insulin are described. The determination of insulin-specific antibodies showed relatively high IgE-antibody titers in contrast to low IgG-antibody concentrations, which is in accordance with the assumption that the ratio of IgE- to IgG-insulin antibodies is important in the outcome of clinically manifest allergic reactions. Negative results for cutaneous delayed-type insulin hypersensitivity and for stimulation of lymphocyte blastogenesis exclude type IV immunopathogenic reaction in this insulin-allergic patient. Preliminary data suggest that inherited individual factors--such as DR2, DR3 positivity in this diabetic individual--might predispose diabetic patients to insulin allergy. |
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Authors:
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G Schernthaner; H Ludwig; R Jarisch; H Bruneder |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Diabetes care Volume: 4 ISSN: 0149-5992 ISO Abbreviation: Diabetes Care Publication Date: 1981 Mar-Apr |
Date Detail:
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Created Date: 1981-06-13 Completed Date: 1981-06-13 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7805975 Medline TA: Diabetes Care Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 196-201 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Animals Diabetes Complications Diabetes Mellitus / drug therapy, immunology* Female Humans Hypersensitivity, Immediate* Insulin / pharmacology, therapeutic use* Insulin Antibodies* Lymphocyte Activation / drug effects Skin Tests Species Specificity Swine |
| Chemical | |
Reg. No./Substance:
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0/Insulin Antibodies; 11061-68-0/Insulin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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