Document Detail

Immediate-type allergy against insulin itself: clinical and immunologic studies on a diabetic patient with insulin intolerance.
MedLine Citation:
PMID:  7011726     Owner:  NLM     Status:  MEDLINE    
In this report clinical and immunologic data of a female diabetic patient with immediate-type allergy against insulin preparations of different species, including pancreatic human insulin, biosynthetic human insulin and semisynthetic human insulin are described. The determination of insulin-specific antibodies showed relatively high IgE-antibody titers in contrast to low IgG-antibody concentrations, which is in accordance with the assumption that the ratio of IgE- to IgG-insulin antibodies is important in the outcome of clinically manifest allergic reactions. Negative results for cutaneous delayed-type insulin hypersensitivity and for stimulation of lymphocyte blastogenesis exclude type IV immunopathogenic reaction in this insulin-allergic patient. Preliminary data suggest that inherited individual factors--such as DR2, DR3 positivity in this diabetic individual--might predispose diabetic patients to insulin allergy.
G Schernthaner; H Ludwig; R Jarisch; H Bruneder
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Diabetes care     Volume:  4     ISSN:  0149-5992     ISO Abbreviation:  Diabetes Care     Publication Date:    1981 Mar-Apr
Date Detail:
Created Date:  1981-06-13     Completed Date:  1981-06-13     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7805975     Medline TA:  Diabetes Care     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  196-201     Citation Subset:  IM    
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MeSH Terms
Diabetes Complications
Diabetes Mellitus / drug therapy,  immunology*
Hypersensitivity, Immediate*
Insulin / pharmacology,  therapeutic use*
Insulin Antibodies*
Lymphocyte Activation / drug effects
Skin Tests
Species Specificity
Reg. No./Substance:
0/Insulin Antibodies; 11061-68-0/Insulin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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