| Immediate and simultaneous sensory reorganization at cortical and subcortical levels of the somatosensory system. | |
| | |
MedLine Citation:
|
PMID: 9256499 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The occurrence of cortical plasticity during adulthood has been demonstrated using many experimental paradigms. Whether this phenomenon is generated exclusively by changes in intrinsic cortical circuitry, or whether it involves concomitant cortical and subcortical reorganization, remains controversial. Here, we addressed this issue by simultaneously recording the extracellular activity of up to 135 neurons in the primary somatosensory cortex, ventral posterior medial nucleus of the thalamus, and trigeminal brainstem complex of adult rats, before and after a reversible sensory deactivation was produced by subcutaneous injections of lidocaine. Following the onset of the deactivation, immediate and simultaneous sensory reorganization was observed at all levels of the somatosensory system. No statistical difference was observed when the overall spatial extent of the cortical (9.1 +/- 1.2 whiskers, mean +/- SE) and the thalamic (6.1 +/- 1.6 whiskers) reorganization was compared. Likewise, no significant difference was found in the percentage of cortical (71.1 +/- 5.2%) and thalamic (66. 4 +/- 10.7%) neurons exhibiting unmasked sensory responses. Although unmasked cortical responses occurred at significantly higher latencies (19.6 +/- 0.3 ms, mean +/- SE) than thalamic responses (13. 1 +/- 0.6 ms), variations in neuronal latency induced by the sensory deafferentation occurred as often in the thalamus as in the cortex. These data clearly demonstrate that peripheral sensory deafferentation triggers a system-wide reorganization, and strongly suggest that the spatiotemporal attributes of cortical plasticity are paralleled by subcortical reorganization. |
| | |
Authors:
|
B M Faggin; K T Nguyen; M A Nicolelis |
Related Documents
:
|
1496379 - Neuronal domains in developing neocortex. 1541349 - Cortical modulation of thalamo-cortical neurons relaying exteroceptive information: a m... 23300109 - Prestimulus beta power and phase synchrony influence the sound-induced flash illusion. 6736289 - Ipsilateral cortical connections from the second and fourth somatic sensory areas in th... 9163549 - A non-thalamic pathway contributes to a whole body map in the brain of the budgerigar. 11470329 - Deprivation and denervation differentially affect zinc-containing circuitries in the ba... 22960149 - Greater sensitivity to nonaccidental than metric changes in the relations between simpl... 10742719 - Presynaptic and postsynaptic relations of mu-opioid receptors to gamma-aminobutyric aci... 18184889 - Local circuit connections between hamster laminae iii and iv dorsal horn neurons. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Proceedings of the National Academy of Sciences of the United States of America Volume: 94 ISSN: 0027-8424 ISO Abbreviation: Proc. Natl. Acad. Sci. U.S.A. Publication Date: 1997 Aug |
Date Detail:
|
Created Date: 1997-09-17 Completed Date: 1997-09-17 Revised Date: 2009-11-18 |
Medline Journal Info:
|
Nlm Unique ID: 7505876 Medline TA: Proc Natl Acad Sci U S A Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 9428-33 Citation Subset: IM |
Affiliation:
|
Department of Neurobiology, Duke University Medical Center, Durham, NC 27710, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Neuronal Plasticity* Psychomotor Performance / physiology* Rats Somatosensory Cortex / physiology* |
| Grant Support | |
ID/Acronym/Agency:
|
DE-111121-01/DE/NIDCR NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: A single dose of kainic acid elevates the levels of enkephalins and activator protein-1 transcriptio...
Next Document: Carboxyfullerenes as neuroprotective agents.